In our previous study, a prolactin elevation was more frequently in risperidone than in blonanserin; however, it was more often in blonanserin than in olanzapine. Therefore, while a rate of PRL rising is low to moderate, hyperprolactinemia is a considerable adverse effect in the blonanserin treatment. In this study, to examine detailed characteristics of hyperprolactinemia of blonanserin, we an...

In developed countries, the elderly population increases at an accelerated rate due to a decrease in the birth rate and the prolongation of life through medical development. Moreover, increases in the elderly population allow the prediction of an increase in hyperprolactinemia caused by aging. It is well known that hyperprolactinemia decreases libido and causes oligozoospermia [1]. On the other...

OBJECTIVE The aim was to formulate practice guidelines for the diagnosis and treatment of hyperprolactinemia. PARTICIPANTS The Task Force consisted of Endocrine Society-appointed experts, a methodologist, and a medical writer. EVIDENCE This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the...

Prolactin is of interest in the pathogenesis of systemic lupus erythematosus (SLE) because almost 25% of SLE patients display hyperprolactinemia, and serum prolactin correlates with disease activity in some patients. Furthermore, hyperprolactinemia causes early mortality in lupus-prone mice and induces a lupus-like phenotype in nonspontaneously autoimmune mice. We show here that the immunomodul...

Autonomous secretion of prolactin (PRL) by a pituitary prolactinoma is a relatively common endocrine disorder characterized by increased serum concentrations of PRL and symptoms of menstrual irregularity, infertility, and galactorrhea in women and impotence and lack of libido in men (1 ). These clinical symptoms are common, and measurement of serum PRL is a key investigation used to identify th...

Cabergoline is a new long-acting dopamine agonist that is very effective and well tolerated in patients with pathological hyperprolactinemia. The aim of this study was to examine, in a very large number of hyperprolactinemic patients, the ability to normalize PRL levels with cabergoline, to determine the effective dose and tolerance, and to assess the effect on clinical symptoms, tumor shrinkag...

OBJECTIVE To provide practical and up to date recommendations for evaluation, differential diagnosis, and treatment of prolactinoma and hyperprolactinemia in various clinical settings. PARTICIPANTS Members of the Neuroendocrinology Working Group of the Spanish Society of Endocrinology. METHODS Recommendations were formulated according to the Grading of Recommendations, Assessment, Developme...

Background: Hyperprolactinemia is the most common endocrine disorder in hypothalamic-pituitary axis and has been reported in variable levels in patients with overt primary hypothyroidism. We decided to determine the prevalence of hyperprolactinemia and clinical related symptoms in subclinical hypothyroidism patients. Methods: In this cross sectional study, prolactin levels of 481 subclinical hy...

background: the association of endometriosis with hyperprolactinemia is controversial. objective: the present study aimed to determine the frequency of endometriosis and association of prolactin with endometriosis in infertile women. materials and methods: 256 infertile women who underwent diagnostic laparoscopy for the evaluation of infertility, referred to fatemezahra infertility and reproduc...