OBJECTIVE Non-dipper hypertension is associated with an increased cardiovascular morbidity and mortality. Besides this, the left atrial (LA) size and functions are accepted to be prognostic factors in various cardiovascular diseases. In this study, we aimed to evaluate the effect of nondipper hypertension on LA volume and functions using real-time three-dimensional echocardiography (RT3-DE). ...

Hypertension resistant to 2 antihypertensive drugs is more common among obese patients than among lean patients. The case we describe and the observations we report suggest that refractoriness among obese hypertensives is frequently caused by obstructive sleep apnea and/or inappropriately high plasma aldosterone levels. In other words, obese hypertensives may have sleep apnea, obese hypertensiv...

BACKGROUND Recent studies have demonstrated the antihypertensive effect of slow breathing exercises, guided interactively by a device, in patients with uncontrolled blood pressure (BP) without changing medication. This study examined the response to the same treatment protocol in resistant hypertensives. METHODS Seventeen resistant hypertensives exercised device-guided slow breathing for 8 we...

To test the hypothesis that abnormal platelet Ca2+ handling in essential hypertension results from cellular Mg2+ deficiency, cytosolic free Mg2+ concentration ([Mg2+]i) and Ca2+ metabolism were studied in mag-fura 2 and fura 2-loaded platelets from 30 essential hypertensive patients and 30 sex- and age-matched normotensive controls. Basal cytosolic free Ca2+ concentration ([Ca2+]i) and intracel...

About 30",, of patients seen in our lipid clinic during 1976 had raised blood pressure, and many patients attending the hypertension clinic have hyperlipidaemia. This apparent association between hypertension and hyperlipidaemia could have arisen because hypertensives tend to have lipid concentrations measured more frequently than people with no risk factors for vascular disease, or might have ...

INTRODUCTION Blood pressure (BPR) control in people of African descent is poor, largely because of a lack of treatment. Although the requirements for immediate initiation of antihypertensive drug therapy are defined by global cardiovascular risk, the global cardiovascular risk profiles of untreated hypertensives at a community level are uncertain. AIM To identify the distribution of global ca...

Direct intravital microscopy was used to analyze microclrculatory changes in the exteriorized spinotrapezius muscle of spontaneously hypertensive rats (SHR). The animals were anesthetized with a mixture of chloralose-urethane, and measurements made of pressure, flow, and resistance in vessels ranging in size from 50 to 5 Mm. Tbe vascular changes in SHR were compared with matched Wistar-Kyoto (W...

BACKGROUND Blood pressure (BP) control in hypertensives is important in preventing cardiovascular (CV) morbidity and mortality. This work was done to assess control of BP among Nigerian hypertensives at rest and during exercise. MATERIALS AND METHODS A total of 85 male hypertensives were recruited consecutively and had clinical evaluation and treadmill (TM) exercise testing using the Bruce pr...

AIMS The objective of the study was to investigate the influence of a history of arterial hypertension on long-term prognosis after an acute myocardial infarction in a representative population, and secondly to assess the impact on prognosis of left ventricular systolic function in hypertensives after acute myocardial infarction. METHODS A retrospective analysis of survival data on 6676 patie...

CONTEXT There is strong evidence for a physiological hyperreactivity to stress in systemic hypertension, but data on associated or potentially moderating psychological factors are scarce. OBJECTIVE The objective of the study was to identify psychological correlates of physiological stress reactivity in systemic hypertension. DESIGN This was a cross-sectional, quasi-experimentally controlled...