The striking clinical and pathologic features of hypertrophic cardiomyopathy have been defined almost exclusively in the young. Little is known about this condition in the elderly, although it is assumed to be part of a single disease. Accordingly, we studied 28 patients who were 65 years of age and older (mean age, 72 +/- 6.4 years) who were diagnosed as having hypertrophic cardiomyopathy by M...

An active, healthy, and symptom free 16 year old boy with a family history of hypertrophic cardiomyopathy died suddenly while walking home from school. Necropsy showed absence of left ventricular hypertrophy (that is, normal heart weight), though the characteristic histological abnormalities of hypertrophic cardiomyopathy, such as cardiac muscle cell disorganisation and abnormal intramural coro...

In 1957, Brock 1 described 3 patients with hypertrophic cardiomyopathy of which one of these patients had previously been hypertensive. Brock postulated that obstruction of the left ventricle outflow tract was caused by concentric hypertrophy of the subvalvular region of the left ventricle, which in turn resulted in sustained systemic hypertension. Later in 1970, Hambly 2 reported 8 cases of hy...

OBJECTIVE To estimate the total number of patients with idiopathic cardiomyopathy in Japan and the prevalence of the disorder. DESIGN A nationwide epidemiological survey. SETTING Hospitals selected randomly from among all hospitals in Japan. PATIENTS Patients presenting with any of the three types of idiopathic cardiomyopathy: dilated cardiomyopathy, hypertrophic cardiomyopathy, and restr...

TOPIC: Cardiovascular Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: Apical hypertrophic cardiomyopathy (AHCM) is an uncommon variant of (HCM). Significantly, sudden cardiac death less likely to occur in patients with isolated AHCM, and overall cardiovascular morbidity may be common than other HCM phenotypes. Available outcome studies are insufficiently powered for robust con...

Hypertrophy From Apical Hypertrophic Cardiomyopathy To the Editor: We read with interest the article by Reddy et al1 regarding a case with apical hypertrophic cardiomyopathy. The authors said that the 2D echocardiograph obtained from this patient indicated hypertrophy of the apex and that 201-Tl scintigraphic imaging demonstrated an increased count in the apical segment. However, because there ...

. Arad M, Maron BJ, Gorham JM, et al. Glycogen storage diseases presenting as hypertrophic cardiomyopathy. N Engl J Med 2005;352:362–72. . Dougu N, Joho S, Shan L, et al. Novel LAMP-2 mutation in a family with Danon disease presenting with hypertrophic cardiomyopathy. Circ J 2009;73:376–80. . Maron BJ, Seidman JG, Seidman CE. Proposal for contemporary screening strategies in families with hyper...

McKenna WJ. Prospective prognostic assessment of blood pressure response during exercise in patients with hypertrophic cardiomyopathy. Circulation 1997;96:2987–2991. 29. Maron BJ. Hypertrophic cardiomyopathy: a systematic review. JAMA 2002;287:1308–1320. 30. Spirito P, Bellone P, Harris KM, Bernabo P, Bruzzi P, Maron BJ. Magnitude of left ventricular hypertrophy and risk of sudden death in hype...

AIM We describe a case of non-obstructive apical hypertrophic cardiomyopathy with atrial septal defect, in a 48-year-old caucasian female patient with chronic renal failure, hypothyroidism and primary amenorrhea, referred to our hospital for syncope, palpitation and shortness of breath. METHODS AND RESULTS Electrocardiogram, transthoracic echocardiogram and cardiac magnetic resonance showed c...

OBJECTIVE The goal was to identify the clinical variables associated with establishing a cause of cardiomyopathy in children. METHODS The Pediatric Cardiomyopathy Registry contains clinical and causal testing information for 916 children who were diagnosed as having cardiomyopathy in North America between 1990 and 1995. Children with a causal diagnosis were compared with those without with re...