This study was planned to determine the prevalence of hypodontia in permanent dentition and to test whether an association was present between hypodontia and Angle's malocclusion. The retrospective study was conducted at a tertiary care hospital, Karachi, and comprised record of all patients visiting the orthodontic clinics of the hospital from 2005 to 2015. Orthodontic records of 790(79%) subj...

We conducted a comprehensive meta-analysis of 4 case-control studies to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-β1 (TGF-β1) genes and hypodontia. A total of 643 tooth agenesis cases and 733 healthy controls were included in this study. The meta-analysis results showed that the T allele and T carrier (CT + TT) of rs1095 in the MSX1 ge...

Thosen (Amer. J. phys. Anthrop., [n.s. 10:155, 1952) listed dominant, irregular donsinant, recessive, and sex-linked genes as the explanation for hypodontia. Grahnhn (Odont. Revy, 7, Sup)pl. 3, 1956) concluded from studies of Swedish families that dominant genes were involved in the majority of cases of hypodontia and that probably a number of genetic entities were associated with its occurrenc...

Congenital Tooth Agenesis or Hypodontia is one of the most common developmental anomaly of the human dentition, presents itself with one or more missing teeth. It is a polygenetic disorder that can occur either in isolation or as a co-finding in many syndromes. The Clinical features, diagnostic characteristics and management strategies all depend on the severity of the condition, presence or ab...

ectodermal dysplasia is a hereditary disorder associated with abnormal development of embryonic ectodermally-derived organs including teeth, nails, hair and sweat glands. hypodontia of the primary and permanent dentition is the most common oral finding. therefore, affected patients need dental prosthetic treatments during their developmental years. this report presents two cases of children aff...

gardner’s syndrome is a genetic condition demonstrating an autosomal dominant trait and characterized by the multiple colonic polyps (familial adenomatous polyposis coli) with sebaceous cysts and jaw osteomas. various dental abnormalities present in patient’s suffering with this syndrome includes multiple impacted or unerupted teeth, supernumerary teeth, hypodontia, compound odontomes and denti...