The antidiabetic effect of seeds of Strychnos potatorum Linn. was evaluated in a model of diabetes mellitus using streptozotocin (40 mg/kg b.w., i.p.). Changes in fasting blood sugar were estimated periodically for 12 weeks along with weekly measurement of body weight, food and water intake for 4 weeks. The antidiabetic effects were compared with glipizide as the reference hypoglycemic drug. St...

Cuscuta reflexa (whole plant) and Calotropis procera (leaves) are used in folk medicine of Bangladesh to control blood sugar in patients suffering from diabetes mellitus. The hypoglycemic effects of methanol and chloroform extracts of whole plants of Cuscuta reflexa, and methanol extract of leaves of Calotropis procera were investigated in oral glucose tolerance tests in Long Evans rats and Swi...

The present study investigated the possible antiobesity and hypoglycemic effects of phloretin (Ph). In an attempt to discover the hypoglycemic effect and potential mechanism of Ph, we used the streptozotocin-induced diabetic rats and (L6) myotubes. Daily oral treatment with Ph for 4 weeks significantly (P<0.05) reduced postprandial blood glucose and improved islet injury and lipid metabolism. G...

The effect of several hypoglycemic sulphonylureas upon the oxidative phosphorylation of intact rat liver mitochondria was examined. Following results were obtained and discussed in relation to hypoglycemic action and uncoupling site of these drugs. 1. All hypoglycemic sulphonylurea drugs tested, i.e., tolbutamide, carbutamide, chlorpropamide, acetohexamide, glybenclamide, and glyclopyramide wer...

in an effort to evaluate the hypoglycemic activity of t. polium, the crude extract was administered orally to a group of streptozotocin induced diabetic rats for 6 consecutive weeks. significant decrease in blood glucose by 64%, total bilirubin by 35%, glutamate oxaloacetate transferase by 48% and glutamate pyruvate transferase by 30% was observed compared to untreated diabetic rats. however, t...

This work was to investigate the hypoglycemic and antioxidant activities of the exopolysaccharides produced in a stirred-tank bioreactor by Inocutus hispidus. The exopolysaccharides showed significant antioxidant activities, up to 70.7±2.5% inhibition of hydroxyl radicals, 50% inhibition of 2,2-diphenyl-1-picrylhydrazyl radicals, and a Trolox equivalent antioxidant capacity of 3.3 mM. The exopo...

The objective of the study is to evaluate the hypoglycemic activity of Barringtonia acutangula (BA) fruit extracts i.e. aqueous, methanol and chloroform in streptozotocin (STZ) 50mg /kg induced hyperglycemic Wistar rats. In addition, the effect off all the three extracts of BA fruit on oral glucose tolerance in glucose loaded normal rats was also determined. Aqueous extract (400 mg/kg) treatmen...

      The present study was carried out to determine the hypoglycemic activity of the methanolic extract and solvent fractions (n-hexane and ethyl acetate) of Ruellia tuberosa in normal and alloxan-induced diabetic rabbits. Optimum dose of R. tuberosa for hypoglycemic activity was determined by oral administration of the methanolic extract (ME) to normal and diabetic ...