Beta-glucuronidase (βG) is a potential biomarker for cancer diagnosis and prodrug therapy. The ability to image βG activity in patients would assist in personalized glucuronide prodrug cancer therapy. However, whole-body imaging of βG activity for medical usage is not yet available. Here, we developed a radioactive βG activity-based trapping probe for positron emission tomography (PET). We gene...

Transmission phase alpha measurements of many-electron quantum dots (small mean level spacing delta) revealed universal phase lapses by pi between consecutive resonances. In contrast, for dots with only a few electrons (large delta), the appearance or not of a phase lapse depends on the dot parameters. We show that a model of a multilevel quantum dot with local Coulomb interactions and arbitrar...

We introduce quantum maps with particle-hole conversion (Andreev reflection) and particle-hole symmetry, which exhibit the same excitation gap as quantum dots in the proximity to a superconductor. Computationally, the Andreev maps are much more efficient than billiard models of quantum dots. This makes it possible to test analytical predictions of random-matrix theory and semiclassical chaos th...

We investigate the Kondo effect in a quantum dot with almost degenerate spin-singlet and triplet states for an even number of electrons. We show that the Kondo temperature as a function of the energy difference between the states Delta reaches its maximum around Delta = 0 and decreases with increasing Delta. The Kondo effect is thus enhanced by competition between singlet and triplet states. Ou...

We study the effect of electron hopping in triple quantum dots modeled by the three-impurity Anderson model. We determine the range of hopping parameters where the system exhibits the two-channel Kondo effect and has non-Fermi-liquid properties in a wide temperature interval. As this interval is entered from above, the conductance through the side dots increases to a half of the conductance qua...

We study a set of cooperatively interacting units at criticality, and we prove with analytical and numerical arguments that they generate the same renewal non-Poisson intermittency as that produced by blinking quantum dots, thereby giving a stronger support to the results of earlier investigation. By analyzing how this out-of-equilibrium system responds to harmonic perturbations, we find that t...

The capacitive couplings between gate-defined quantum dots and their gates vary considerably as a function of applied gate voltages. The conversion between gate voltages and the relevant energy scales is usually performed in a regime of rather symmetric dot-lead tunnel couplings strong enough to allow direct transport measurements. Unfortunately, this standard procedure fails for weak and possi...

We propose non-negative matrix factorisation with iterative restarts (iNMF) to model a noisy dataset of highly overlapping fluorophores with intermittent intensities. We can recover high-resolution images of individual sources from the optimised model, despite their high mutual overlap in the original data. Each source can have an arbitrary, unknown shape of the PSF and blinking behaviour. This...

We perform self-consistent quantum transport calculations in open quantum dots taking into account the effect of electron interaction. We demonstrate that, in the regime of the ultralow temperatures 2 pi kappa BT < or = delta (delta being the mean-level spacing), the electron interaction strongly smears the conductance oscillations and thus significantly affects their statistics. Our calculatio...

Numerical results for transport properties of two coupled double-level quantum dots (QDs) strongly suggest that under appropriate conditions the dots develop a novel ferromagnetic (FM) correlation at quarter filling (one electron per dot). In the strong coupling regime (Coulomb repulsion larger than electron hopping) and with interdot tunneling larger than tunneling to the leads, an S=1 Kondo r...