نتایج جستجو برای: icam1 gene
تعداد نتایج: 1141596 فیلتر نتایج به سال:
The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated T-LBL onset while inhibiting progression to T-ALL. The T-LBL cells failed to invade the vasculature and showed evidence of increased homotypic cell-cell adhesion and autophag...
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic worldwide. Left untreated, it can be a risk factor for developing cirrhosis or hepatocellular carcinoma (HCC). Although experts have made many efforts to find underlying mechanisms NAFLD, they remain mystery. Objectives: This study aimed distinguish gene signatures and pathways in human during NAFLD progress...
Objective(s): Fluvoxamine is a well-known selective serotonin reuptake inhibitor (SSRI); Despite its anti-inflammatory effect, little is known about the precise mechanisms involved. In our previous work, we found that IP administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. In this study, we aimed to evaluate the effect of fluvoxa...
Abstract BACKGROUND Glioblastoma (GBM) is an aggressive and highly fatal brain cancer in adults. Existing treatment methods are ineffective we need of new treatments that extend the overall survival improve quality-of-life. Cell adhesion molecules (CAMs) proteins enable cells to communicate with one another surrounding environment. Intracellular molecule 1 (ICAM1) a CAM expressed by TAMs GBM. T...
We revise the limits on the FCNC higgses in manifestly left-right symmetric theories. It is shown that the combination of the Kobayashi-Maskawa CP-violation with the tree level ∆S = 2 higgs exchange gives very large contribution to the CPviolating ǫ parameter. It leads to the new strong constraint on the FCNC higgs mass, M > 50 − 100 TeV, enhanced almost by factor of the order √ mt/mc. Being ad...
Soft scalar masses in supergravity with horizontal U(1) X gauge symmetry Abstract In supergravity with modular invariance and horizontal U (1) X gauge symmetry there is a relation between modular weights and U (1) X charges. The soft scalar masses are then strongly correlated with Yukawa matrices. The implications for FCNC are discussed.
Recent studies of the interferon-induced transcription factor STAT1 have associated its dysregulation with poor prognosis in some cancers, but its mechanistic contributions are not well defined. In this study, we report that the STAT1 pathway is constitutively upregulated in type II endometrial cancers. STAT1 pathway alteration was especially prominent in serous papillary endometrial cancers (S...
We have identified waved 3 (wa3), a novel recessive mutation that causes abnormalities of the heart and skin. The cardiac defect results in a severe and rapidly progressive dilated cardiomyopathy. We identified the gene mutated in these mice, which we call NFkB interacting protein1 (Nkip1), using positional cloning. Nkip1 is expressed in skin, heart and vascular endothelium and shares homology ...
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