نتایج جستجو برای: idarubicin
تعداد نتایج: 767 فیلتر نتایج به سال:
BACKGROUND Although survival of children with acute lymphoblastic leukaemia has improved greatly in the past two decades, the outcome of those who relapse has remained static. We investigated the outcome of children with acute lymphoblastic leukaemia who relapsed on present therapeutic regimens. METHODS This open-label randomised trial was undertaken in 22 centres in the UK and Ireland and ni...
We show that treating human trisomic fibroblasts with anthracyclines – aclarubicin, daunorubicin and idarubicin – leads to certain changes in these cells; namely the activation of caspase 3, morphological changes and an increase in the level of intracellular calcium. These results suggest that anthracycline drugs are also able to induce apoptosis in pathological, trisomic cells.
Preliminary independent reports of the Italian GIMEMA and the Spanish PETHEMA trials for newly diagnosed acute promyelocytic leukemia (APL) indicated a similarly high antileukemic efficacy in terms of complete remission and disease-free survival rates. To better investigate these studies and the prognostic factors influencing relapse risk, this study analyzed the updated results of 217 patients...
(Korf, Reid, & Edelkamp 2001) introduced a formula to predict the number of nodes IDA* will expand given the static distribution of heuristic values. Their formula proved to be very accurate but it is only accurate under the following limitations: (1) the heuristic must be consistent; (2) the prediction is for a large random sample of start states (or for large thresholds). In this paper we gen...
Visuzalizing time information using a timeline has been done for over 250 years. Using a timeline can assist users in making sense of time data which could otherwise be hard to understand. A timeline has been implemented at Ida Infront, and its purpose is to help managers understand how cases are progressing in a case management system created by Ida Infront. The timeline is designed using usab...
s for Invited Talks Probabilistic Techniques for Mobile Robot Navigation, Wolfram Burgard . . . 7 Large-Scale Bilingual Extraction and Validation of Structured Patent Terminology, Magnus Merkel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Constraint Programming for Real, Christian Schulte . . . . . . . . . . . . . . . 11
A 53-year-old man was admitted with pancytopenia, fever and splenomegaly. Biochemistry showed increased ferritin levels. Bone marrow examination revealed increased erythrocytic precursors (94.9%) and active hemophagocytosis. Pure erythroid leukemia with hemophagocytic syndrome (HPS) was diagnosed. Induction chemotherapy comprising idarubicin and cytarabine was administered and steroid pulse the...
There is evidence that the interaction of the α-ketol group of the Doxorubicin and Epirubicin anti-cancer drugs with Fe(III) generates hydroxyl radicals under aerobic conditions, causing cardiotoxicity in patients. Considering that the formation of DNA adducts is one of the main targets of Anthracycline drugs, we have in the present study characterized several [Anthracycline-DNA]Fe(III) complex...
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