Tryptophan (Trp) is present in the serum, partly bound to albumine and in the free form. The unbound portion of circulating tryptophan has the property of crossing the hematoencephalic barrier and being converted within the brain into serotonin (5-HT) through the enzymatic processes of hydroxylation and decarboxylation. The serotoninergic system plays an important role in neuroendocrine control...

Abstract Introduction Craniopharyngiomas are rare tumors that arise from Rathke’s pouch remnants along the pituitary-hypothalamic axis. The tumor and its treatment can lead to significant neurological endocrinological complications including alterations in appetite, endocrine insufficiency, circadian rhythms sleep. We report case of a woman who developed hypersomnia following resection cranioph...

Amenorrhoea is the constant feature of Anorexia Nervosa (AN), caused by sharp metabolism reduction gonadotropines as compared with prepubertal level, but its exact mechanism unknown. Biochemical mediators, involved in this process, include cortisol, leptin, growth hormone (GH), insulin-like factor (IGF-1) and cytokines. Experimental investigation that produced fat cells, plays a role metabolic ...

BACKGROUND Cabergoline is a long-acting dopamine-agonist drug that suppresses prolactin secretion and restores gonadal function in women with hyperprolactinemic amenorrhea. We designed a study to compare its safety and efficacy with those of bromocriptine, which has been the standard therapy. METHODS A total of 459 women with hyperprolactinemic amenorrhea were treated with either cabergoline ...