Background: IL-17/IL-23 axis plays an important role in the pathogenesis of several autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). The immunomodulatory properties of ginger are reported in previous studies. Objective: To evaluate the effects of ginger extract on the expression of IL-17 and IL-23 in a model of EAE. Methods: EAE was induc...

Macrophages are involved in low-grade inflammation in diabetes, and play pathogenic roles in proliferative diabetic retinopathy (PDR) by producing proinflammatory cytokines. T cells as well as other cells are also activated by proinflammatory cytokines, and infiltration into the vitreous of patients with PDR has been shown. In this study, we measured helper T (Th) cell-related cytokines in the ...

Abstract Canine atopic dermatitis (CAD) is a prevalent genetically susceptible inflammatory and pruritic allergic skin condition affecting not only the health of dogs but also quality life their owners. Interleukin-31 (IL-31) interleukin-31 receptor alpha (IL-31RA) are essential for development pruritus in primates mice. Hence, it expected that inhibiting IL-31RA will be an effective approach t...

Atopic dermatitis (AD) is a chronic, recurrent, itchy eczematous disorder associated with impaired skin barrier functions. The coexistence of anxiety, depression, and social withdrawal problematic in AD. At present, psychological factors such as stigma resulting from appearance insomnia pruritus are possible causes, but the detailed causes depression anxiety AD unknown. Here we hypothesized tha...

European Journal of ImmunologyVolume 51, Issue 1 Back CoverFree Access cover story: Eur. J. Immunol. 1'21 First published: 12 January 2021 https://doi.org/10.1002/eji.202170018AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have r...

Atopic dermatitis (AD) is a chronic, recurrent, itchy, inflammatory skin disease. The coexistence of anxiety, depression, and social withdrawal problematic in AD. Although an association between AD anxiety depressive behavior has been observed humans few mouse models, the detailed mechanisms are unknown. To address this issue, we analyzed mental state mice using models. We sensitized with 3% ox...

BACKGROUND/AIMS Our aim is to assess the relationship between interleukin 1β (IL-1 β), (-511,-31 alleles), interleukin 1RN (IL-RN), Helicobacter pylori (HP) status and gastroesophageal reflux disease (GERD) diagnosed by pH monitoring in the Turkish population. MATERIALS AND METHODS A Total of 100 consecutive patients with GERD were enrolled in the study. Genotypes of IL-1β (-511,-31), IL-1RN ...

Interleukin (IL) 31Ralpha (glycoprotein 130-like monocyte receptor and glycoprotein 130-like receptor) heterodimerizes with oncostatin M receptor beta to bind IL-31, a cytokine expressed preferentially by CD4(+) T helper type 2 (Th2) cells. However, the functions of IL-31-IL-31R signaling in immune regulation remain unknown. Here, we identify a novel role for IL-31R in limiting type 2 inflammat...

IL-31 receptor blockade suppresses pruritus of atopic dermatitis. However, cell type-specific contributions to itch, its expression mechanism, and the downstream signaling pathway induce itch remain unknown. Here, using conditional knockout mice, we demonstrated that IL-31-induced required sensory neuronal STAT3. was decreased in STAT3 deficient indicating dependent on neurons. In addition, an ...