نتایج جستجو برای: il7r
تعداد نتایج: 206 فیلتر نتایج به سال:
The traditional maximum dose density chemotherapy renders the tumor patients not only the tumor remission but the chemotherapy resistance and more adverse side effects. According to the widely positive expression of Toll-like receptor (TLR)-3 in oral squamous cell carcinoma (OSCC) patients (n = 166), we here provided an alternative strategy involved the orderly treatment of TLR3 agonist polyino...
Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of multiple sclerosis show autoimmune features and depend partly on genetic factors. Of these genetic factors, only the HLA gene complex has been repeatedly confirmed to be associated with multiple sclerosis, de...
Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesion in immature/ETP-ALL. Using a conditional gain-of-function mouse model, we demonstrate that sustained Zeb2 expression initiates T-cell le...
c-Myb is a transcription factor with functions in many hematopoietic lineages. c-Myb-deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage. We demonstrate that conditional deletion of c-Myb in B-cell progenitors completely abolishes B-cell development. c-Myb i...
Gastric carcinoma (GC) results in the most cancer mortality worldwide. Germline mutations CDH1 gene, encoding for E-cadherine protein, are common Hereditary Diffuse Carcinoma (HDGC). Mutations alpha Catenin ( CTNNA1 ) have also been identified as an additional genetic cause of HDGC. The identification hereditary susceptibility genes is essential step understanding basic molecular events tumorig...
Artistic representation of the interleukin-7 receptor complex in the plasma membrane of a cell. Editorials 1237 A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome 1240 JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications Lorraine Springuel, ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید