Spergualin exhibited a strong antitumor effect against L1210(IMC), a tumor cell line which has been maintained in BALB/c X DBA/2 F1 (hereafter called CD2F1) mice in the Institute of Microbial Chemistry. Mice inoculated i.p. with 10(5) cells of L1210(IMC) survived more than 60 days by daily i.p. administration of spergualin for 9 days at 5 mg/kg/day, which was started 1 day after the tumor inocu...

Integrated marketing communication (IMC) emerged during the late twentieth century and its importance has been growing ever since (Grove, Carlson, and Dorsch, 2002; Cornelissen, 2001; Hartley and Pickton, 1999). Owing to the impact of information technology, changes came about in the domains of marketing and marketing communications which led to the emergence of IMC (Kitchen et al., 2004a; Phel...

CONTEXT AND OBJECTIVE The thickness of the carotid intima-media complex (C-IMC) is considered to be a marker of early atherosclerosis, but visual and echogenic changes to the C-IMC can also be noted. The objective here was to evaluate the relationship between cardiovascular risk factors and the echogenicity of the C-IMC and identify those most associated with an "abnormal" C-IMC. DESIGN AND S...

Colon carcinomas frequently express the epidermal growth factor receptor (EGFR), and this expression correlates with more aggressive disease and poor prognosis. Previous studies have shown that EGFR blockade by monoclonal antibody IMC-C225 can inhibit the growth of human colon carcinoma tumor cells in vitro and xenografts of these tumors in athymic mice. In this report, we have studied the in v...

Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an important mechanism of tumor escape from immune system control. Previously, we have demonstrated that the number and function of DC were dramatically reduced in cancer patients. This effect was closely associated with accumulation of immature cells (ImC) in peripheral blood. In this study, we investig...

The mechanical and electrical reliabilities of fine bumps with diameters and heights on the order of scores of microns were studied, considering the growth of the intermetallic compound (IMC) at the interface between a tin bump and a copper thin-film interconnection. It was found that an increase in the thickness of the IMC changed the stress and strain fields around the interface significantly...

This paper analyzes arrival flight track data at Chicago (ORD) and Atlanta (ATL) airports. We investigate distributions of vertical and lateral position at different distances from the runway threshold in instrument meteorological conditions (IMC) and visual meteorological conditions (VMC). In IMC, the observed standard deviations at different distances are similar between the two airports. The...

A anti-slug control requires operation around an open-loop unstable operating point. One solution is to design a robust controller based on a mechanistic model. An alternative and more robust approach is to identify an unstable model of the system based on input-output data. We used a closed-loop step test to identify an unstable linear model. From this, we obtained a second order IMC (Internal...

The instructional manipulation check (IMC) is a methodological tool designed to measure whether participants read the instructions in a survey, and thus, it is frequently used in online studies to identify inattentive participants. However, research on survey design has suggested that participants can infer intentions from prior questions, affecting responses to later questions. As the IMC tell...

PURPOSE Angiogenesis plays an important role in colorectal cancer progression. Stimulation of vascular endothelial growth factor receptor (VEGFR), a transmembrane glycoprotein, results in endothelial mitogenesis. Within this family of receptors, VEGFR 2/kinase-insert-domain-containing receptor (KDR) appear to be principally up-regulated during tumorigenesis. A chimeric anti-KDR antibody, IMC-1C...