In the mol-ecule of the title compound, C(8)H(9)N(3), a new imidazoline derivative, the six- and five-membered rings are slightly twisted away from each other, forming a dihedral angle of 7.96 (15)°. In the crystal structure, neighbouring mol-ecules are linked together by inter-molecular N-H⋯N hydrogen bonds into extended one-dimensional chains along the a axis. The pyridine N atom is in close ...

Imidazoline receptors were first proposed by Bousquet et al., when they studied antihypertensive effect of clonidine. A strong candidate for I1R, known as imidazoline receptor antisera-selected protein (IRAS), has been cloned from human hippocampus. We reported that IRAS mediated agmatine-induced inhibition of opioid dependence in morphine-dependent cells. To elucidate the functional and struct...

C3-Symmetric chiral trisimidazolines with m-chloroperbenzoic acid promoted the organocatalytic oxidation of N-sulfonyl ketimine. The present imidazoline catalysis produced oxaziridines bearing a tetrasubstituted carbon stereogenic center in high yields with up to 87% ee.

A novel series of compounds containing a polar, non-flat 2-imidazoline core was designed based on the SAR information available for aromatic azole cyclooxygenase-2 inhibitors. While the majority of the compounds prepared using an earlier developed imidazoline N-arylation methodology turned out to be inferior to the known COX-2 inhibitors, one lead compound displayed potency (300 nM) comparable ...

Over the past few years, a vast amount of research has shed light on the pharmacology of imidazoline binding sites (I-BS). To date, at least three classes of imidazoline binding sites have been characterised in accordance to their localisation, drug selectivity, proposed signalling pathways and functional roles. The existence of these sites raises the question as to whether an endogenous modula...

Correction for ‘“Give me five” – an amino imidazoline-2-imine ligand stabilises the first neutral five-membered cyclic triel(i) carbenoides’ by Lars Denker et al., Chem. Commun., 2021, 57, 2816–2819, DOI: 10.1039/D1CC00010A.

U over X) pereellt ot the populathe MoH, UNFPX and the Uganda Popution of abont 0() million people lation ,Secretariat A multi-sectoral live in rural areas. IUganda's ccon(oY1V Igama, district task force implements depenids mainly on agriculturc andt the project, x-hiIe IJNFPA and the MoH w xomen contrihutc ((0-SO perecnt of do the overall molnitoring. the labour. \Onien s health, therctore, RE...

Imidazoline obtained from the essential oil contained in Pouteria sapota seed was tested as an environmentally-friendly corrosion inhibitor of 1018 carbon steel CO2 saturated 3.5 % NaCl solution using electrochemical techniques. This imidazoline contains fatty acids with presence long hydrophobic chains, 52.73 unsaturated (oleic and linolenic acids) 40 (palmitic myristic compounds. Polarization...