Two multiple antigen peptides consisting of 6 and 7 aminoa cid residues, respectively, plus a 12-residue fragment, used as a control, all linked to a polylysine core, were used as immunogens in rabbits in order to obtain an immune response. Rabbit antisera against such polymers were then tested in ELISA against a panel of antigens in order to analyze the specificities of the resulting antibodie...

Formalin fixation of passive antibody to tumor cells was effective in modifying subsequently harvested antitumor serum so that the antiserum had diminished reactivity to determinants against which the passively administered antibody was directed. The process of formalin fixation of passive antibody to cells made antigen-antibody bonds more avid without producing nonspecific adherence of antibod...

Three immune sera, raised in rabbits against synthetic peptides corresponding in sequence to predetermined regions of the HLA-DQ histocompatibility antigens, were tested for their ability to recognize phenotypically distinct human lymphoblastoid cell lines. The immune sera readily recognize the immunogen. When tested on the cells, they react poorly but seem to exhibit a certain degree of specif...

1. When vaccine virus and its specific antiserum are brought together, no evidence of stable union between them can be determined by the experimental methods employed. 2. A definite relationship exists between the degree of dilution of a neutral vaccine virus-antiserum mixture and the size of the lesion produced by endermic inoculation of rabbits of any given dilution.

The pneumococci hitherto known as Group IV have been separated into ten types which have been designated by Roman numerals from IV to XIII. These have been correlated as far as possible with the types described by others. The prevalence and mortality of cases due to each type have been estimated in the limited number of cases studied. Laboratory tests indicated that therapeutic antiserums for T...

Antibody prepared against HEp-2 cells inhibited the replication of echovirus I. The number of infective centres was reduced and the cells which were infected produced less virus per cell than control cells. The attachment of virus to cells was not affected. The inhibition was reduced by increasing the multiplicity of infection. Application of antibody 5 min. after virus adsorption at 4 ° reduce...