within a given pedigree can only be explained by a ‘‘second signal.’’ In our patient the nature of this second signal was shown not to be one of the known genes involved in hemophagocytosis. Once intravenous immune globulin and prednisone were started, ferritin and sIL-2R levels did not completely normalize (ferritin, 600-750 mg/L [upper limit of normal, 350 mg/L]; sIL-2R, 4320 U/mL [upper limi...

Nutritional management in rangeland beef cattle systems prioritises optimal body condition scores at calving for improved fertility and reproductive success. However, this focus often overlooks short-term dietary deficiencies before calving, which can lead to adverse outcomes neonatal calves. This review explores the effects of cow malnutrition during periparturient period on colostrum producti...

1. Tozawa T. Enzyme-linked immunoglobulins and their clinical significance. Electrophoresis 1989;10:640–4. 2. Wroblewski F, LaDue JS. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med 1955;90:210–3. 3. Kanno T, Maekawa M, Uchiyama S, Tsutiya S. Criteria for detection of heterozygous individuals with lactate dehydrogenase subunit deficiencies. Clin Chem 1990;36:178–9. 4. Fujita K. De...

Peripheral blood lymphocytes from 27 healthy individuals and from 18 patients with a diverse spectrum of defects in humoral immunity were examined for their capacity to undergo terminal differentiation in vitro. Pokeweed mitogen induced cells from normal persons to synthesize and secrete IgM. IgG, and IgA as detected by Immunofluorescence and incorporation of [(14)C]amino acids, Lymphocytes fro...