Disruption of some RNA decay pathways can result in certain inflammatory diseases and tumor progression humans mice. Exonuclease mediated by ZFP36L family proteins the CCR4-NOT complex regulate quiescence, V(D)J recombination, apoptosis during early stages mammalian lymphocyte differentiation. The RNA-binding protein families ZFP36, ROQUIN, REGNASE are non-redundantly required to suppress inapp...

Abstract In recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive system. Particularly discovery CRISPR-Cas9-based triggered a discussion about how to classify systems. question not been addressed yet transgenerational aspect response. If imm...