We herein report on the development of an extended-gate type organic field-effect transistor (OFET)-based immunosensor for the detection of human immunoglobulin A (IgA). The titration results of IgA exhibited shifts in the transfer characteristics of the OFET sensor device with increasing IgA concentration. A linear detection range from 0 to 10 μg/mL was realized with a detection limit of 2.1 μ...

A new design of an immunosensor for viral molecules based on the ISFET nanoscale structure has been proposed. Physical processes take place inimmunosensor are modeled. The effect modulation surface potential interface between a semiconductor depleted layer (channel) and dielectric during interaction immobilization was used. Analytical expression source-drain current as function virus types conc...

Lab-on-a-chip can provide convenient and accurate diagnosis tools. In this paper, a plastic-based microfluidic immunosensor chip for the diagnosis of swine flu (H1N1) was developed by immobilizing hemagglutinin antigen on a gold surface using a genetically engineered polypeptide. A fluorescent dye-labeled antibody (Ab) was used for quantifying the concentration of Ab in the immunosensor chip us...

A potentiometric immunosensor for the detection of human IgG has been developed using an asymmetric, ion-selective membrane with immobilized adenosine deaminase and IgG. A protein A-alkaline phosphatase conjugate binds to the immobilized IgG, creating a bienzymatic catalytic layer. In the presence of sample IgG, the conjugate does not bind to the membrane. Instead, the intermediate in the two-s...

The first label-free EGOFET immunosensor able to quantitatively detect anti-drug antibodies against Nivolumab, with a LOD of 100 fM.

A novel electrochemiluminescent immunosensor with polymerization-assisted signal amplification has been developed and enhanced sensitivity was achieved by increasing tertiary amine loading on polymers.

The highly characteristic solid-state Ag/AgCl process was used as an ultrasensitive detection mechanism for electrochemical sensors, such as a prostate-specific antigen immunosensor.

In this study a label-free electrochemical Immunosensor for ultrasensitive detection of Hepatitis C virus core antigen in serum samples was fabricated by using a simple approach. In this method a low-cost and sensitive immunosensor was fabricated based on a boehmite nanoparticles (BNPs) modified glassy carbon. The BNPs provide a specific platform with increased surface area which is capable of ...

      A highly sensitive electrochemicalimmunosensor was developed to detect hCG based on immobilization ofhCG-antibody (anti-hCG) onto robust nanocomposite containing Gr, Chit,1-methyl-3-octyl imidazolium tetra fluoro borate ionic liquid (IL)(Gr-IL-Chit). AuNPs were used to immobilize hCG antibody on the modifiedelectrode. The amine groups of the antibody are cova...

Hemin/G-quadruplex-based DNAzyme concatamers were utilized as electrocatalysts and biolabels to construct a sandwich-type electrochemical immunosensor for sensitive detection of IgG1 (as a model analyte).