several studies have shown that decidual tissue produces soluble factors which can mediate a variety of immunosuppressive activities. in order to assess whether prostaglandin e2 (pge2) was present in supernatants produced by explant culture of 10 human specimens of first trimester decidua. the effect of the supernatants from the two different series (with and without indomethacin treatment) of ...

The negative effect of donor-specific antibodies on the success of solid transplant is now clearly established. However, the lack of effective treatment to prevent the development of antibody-mediated lesions deepens the need for clinicians to focus on primary prevention of de novo humoral allosensitization. Among the factors associated with the risk of developing de novo donor-specific antibod...

6-Mercaptopurine and mitomycin C were used in combination drug therapy to produce a prolongation of skin allograft survival.

INTRODUCTION Immunosuppressants are used ubiquitously post-liver transplantation to prevent allograft rejection. However their effects on hepatocytes are unknown. Experimental data from non-liver cells indicate that immunosuppressants may promote cell death thereby driving an inflammatory response that promotes fibrosis and raises concerns that a similar effect may occur within the liver. We ev...

Whereas the standard immunosuppressive agents foster development of posttransplant lymphoproliferative disorders (PTLDs), the impact of RAD, a macrolide with potent immunosuppressive properties, and other immunosuppressive macrolides on these disorders remains undetermined. We found that RAD had a profound inhibitory effect on in vitro growth of six different PTLD-like Epstein-Barr virus+ lymph...

THE RESULTS of kidney transplantation in AfricanAmericans have improved with oetter immunosuppressive regimens. but the overall graft survival is reported by many to be inferior to that of non-Black recipients. 13 The underlying impact of such factors as HLA matching. immunosuppressive regimes. socioeconomic status. or center effect has remained in question as many examine the underlying cause ...

mycophenolic acid is a secondary extracellular metabolite of penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. the aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by penicillium brevi-compactum atcc16024 was investigated. batch submerged fer...

Although tumor cell lysate (TCL) is a type of immunocyte stimulator, its immunosuppressive function must not be ignored. The present study reported that TCL prepared from a Lewis lung cancer cell was able to induce the development of immunosuppressive macrophages (MΦ) and tolerogenic dendritic cells. In addition, TCL upregulated the expression of CD69 in mouse splenocytes, and cell apoptosis an...

the effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. in rat immunized with sheep red blood cells ( srbcs). restraint stress (rs) prevented the booster-induced rise in anti-srbc antibody titre and cell immunity response. intracerebroventicular (i.c>v) injection of histamine (150 µg/rat) induced a similar effect with rs. pretreatment...

polyclonal anti-thymocyte globulin (atg) is used as an immunosuppressive agent in the treatment of aplastic anemia (aa). serum sickness is a recognized side effect of atg. we observed abnormal skin manifestation in patient with aplastic anemia who had been treated with atg. we conclude that abnormal immune function caused by aplastic anemia and atg and corticosteroids may aggravate the signs of...