Indium Tris-thiocarbamates, *H N M R Spectra Indium tris(thiocarbamates) In(S2CN'Pr2)3 (1), In(SOCN'Pr2)3 (2) and In(S2CNC4H4)3 (3) have been synthesized and characterized. Variable temperature *H NM R spectra of 1 and 2 are reported. The X-ray molecular structures of 1 and 3 are found to be quite similar; the symmetry of the In(S2C)3 unit in 3 is close to point group D 3 with small asymmetry i...

introduction: due to the cell labeling potentials of various metal-maltol complexes, the idea of developing a possible cell labeling imaging agent using single photon emission computed chromatography (spect) with[111in]-maltolate complex has been investigated. methods: [111in] labeled 3-hydroxy-2-methyl-4h-pyran-4-onate ([111in]-maltolate) was prepared using freshly prepared [111in]incl3 and ...

Chapter Outline Introduction 105 Multi-Parameter Microscopy of Protein Aggregation Kinetics 106 Fusion Protein Labeling of Amyloidogenic Proteins 106 Principle of Multi-Parameter Imaging Techniques 107 Fluorescence Anisotropy Imaging 107 Principle of HomoFRET in the Study of Protein SelfAssembly Reactions 107 HomoFRET Imaging for the Study of α-synuclein Aggregation 108 Fluorescence Lifetime Im...

BACKGROUND Low uptake ratios, high noise, poor resolution, and low contrast all combine to make the detection of neuroendocrine liver tumours by (111)In-octreotide single photon emission tomography (SPECT) imaging a challenge. The aim of this study was to develop a segmentation analysis method that could improve the accuracy of hepatic neuroendocrine tumour detection. METHODS Our novel segmen...

UNLABELLED Noninvasive monitoring of gene transfer will benefit basic research and patient care. Most gene-transfer imaging systems do not directly detect the gene of interest, and most do not exploit radiopharmaceuticals that have Food and Drug Administration approval for total-body use. (111)In-Octreotide is used clinically to locate tumors overexpressing primarily somatostatin receptor type ...

UNLABELLED Intraoperative visualization techniques promise to significantly improve the detection and resection of tumors. In this study, we used an anti-carcinoembryonic antigen (CEA) antibody (MN-14) tagged with both a radiolabel ((111)In) and a fluorophore (IRDye 800CW) for radionuclide detection and intraoperative fluorescence imaging, respectively. METHODS For this purpose, we prepared a...

Preclinical and clinical studies have demonstrated the application of radiolabeled mAb-PAM4 for nuclear imaging and radioimmunotherapy of pancreatic carcinoma. We have now examined the ability of a novel PAM4-based, bispecific monoclonal antibody (mAb) construct, TF10, to pretarget a radiolabeled peptide for improved imaging and therapy. TF10 is a humanized, bispecific mAb, divalent for mAb-PAM...