Dietary triggers acting on a developing fetus can affect the functioning of the body in later life; this can be observed on various levels, including epigenetic modifications and gene expression. Early-life programmed changes may be transmitted to successive generations. In this study, the impact of prenatal restricted diet was studied in four generations of rats. We hypothesized that this diet...

We show that the recent claim that the 2+1 dimensional Ashtekar formulation for General Relativity has a finite number of physical degrees of freedom is not correct. PACS number(s): 04.20.Cv, 04.20.Fy In a recent paper [1] Manojlović and Miković claim that the number of degrees of freedom in Ashtekar’s formulation for 2+1 dimensional General Relativity is finite at variance with previous result...

Conspicuous asymmetries in forms that are polymorphic within a species can be genetically or environmentally determined. Here, we present a genetic analysis of the inheritance of dimorphic enantiostyly, a sexual polymorphism in which all  owers on a plant have styles that are consistently de ected either to the left or the right side of the  oral axis. Using Heteranthera multi ora (Ponteder...

AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreat...

The Developmental Origins of Health and Disease hypothesis predicts that early-life environmental exposures can be detrimental to later-life health and that mismatch between the pre- and post-natal environment may contribute to the growing non-communicable disease epidemic. Within this is an increasingly recognized role for epigenetic mechanisms; for example, epigenetic modifications can be inf...

Integrins are cell surface receptors crucial for cell migration and adhesion. They are activated by interactions of the talin head domain with the membrane surface and the integrin β cytoplasmic tail. Here, we use coarse-grained molecular dynamic simulations and nuclear magnetic resonance spectroscopy to elucidate the membrane-binding surfaces of the talin head (F2-F3) domain. In particular, we...

Genetic transformation is a potential tool for analyzing gene function and thereby identifying new drug and vaccine targets in parasitic nematodes, which adversely affect more than one billion people. We have previously developed a robust system for transgenesis in Strongyloides spp. using gonadal microinjection for gene transfer. In this system, transgenes are expressed in promoter-regulated f...

We described a method for long-term passive measurements of unattached fraction fp of the potential alpha energy concentration of radon progeny from a set of measured (f1, f2, f3) values, where fi=Ci/C0 (i=1, 2, 3), and C0, C1, C2 and C3 were the concentrations of 222Rn, and the airborne concentrations of 218Po, 214Pb and 214Bi, respectively. Jacobi room model parameters were randomly sampled f...