purpose : to describe a case of successful laser in situ keratomileusis (lasik) retreatment over a previous lasik surgery after 11 years case report : the patient had his first lasik for the correction of -2.25 -1.75×90° and -2.25 -1.00×90° in the right and left eye, respectively. eleven years later, the refraction in the right eye was plano -3.25×80° and he was scheduled for an enhancement pro...

purpose: to report occurrence, management, and outcome of late-onset traumatic dislocation of laser in situ keratomileusis (lasik) flaps case report: we report a patient with late-onset lasik corneal flap dislocation after blunt ocular trauma occurring four years after surgery. an ultrasound biomicroscopy (ubm) was performed to view the status of flap and determination of flap thickness. result...

Tissue loss or organ failure caused by injury or damage is one of the most serious and costly problems in human health care. Tissue engineering, proposed by Langer et al. in the early 1990’s (Langer & Vacanti, 1993), is an emerging strategy of regenerative biomedicine that holds promise for the restoration of defect tissues and organs. The concept of tissue engineering is defined as “the applic...

In the past few years, an increasing number of in situ-forming systems have been reported in the literature for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair. There are several possible mechanisms that lead to in situ gel formation: solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. The thermosensitive ...

PURPOSE An in situ forming hydrogel was evaluated as a potential vitreous substitute in rabbits. METHODS The hydrogel used a disulfide cross-linker that was then reduced to produce an injectable thiol-containing polymer solution. The disulfide cross-links reformed by air oxidation of the thiols and produced a stable hydrogel once inside the eye. The polymer was clear, autoclavable, and could ...

Article history: Received on: 29/05/2014 Revised on: 12/06/2014 Accepted on: 30/06/2014 Available online: 28/07/2014 In this study effect of gamma irradiation sterilization and storage conditions on thermal properties of phase sensitive granisetron in situ forming implant (ISFI) was investigated. ISFI was prepared by mixing Poly (DLlactide-co-glycolide) (PLGA) with dimethylsulfoxide (DMSO) : pr...

AbstractVarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (SLNs). Due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. Different strategies have been employed to overcome this problem. In this direction, the present study introduces erodible in-situ forming gel systems ...