The title compound, [Al(CH(3))(2)(C(25)H(21)N(2)O)(C(4)H(8)O)], was isolated as a minor component from a reaction mixture of the parent indolyl ligand and trimethyl-aluminum in tetra-hydro-furan. The ligands adopt a distorted tetra-hedral geometry around aluminium. Obvious hydrogen-bonding interactions are not present.

Highly efficient and eco-friendly protocol for the synthesis of bis(3-indolyl)methanes by the electrophilic substitution reaction of indole with aldehydes catalyzed by poly(4-vinylpyridinium)hydrogen sulfate was described. Excellent yields, shorter reaction times, simple work-up procedure, avoiding hazardous organic solvents, and reusability of the catalyst are the most obvious advantages of th...

The Au(I)-catalysed rearrangement of propargylic esters formed from an ynamide has been studied. The reaction is facile, and when conducted in the presence of a reactive indole nucleophile, leads to a cascade process whereby γ-indolyl α-acyloxyenamides are formed in good yield and excellent E-stereoselectivity.

The application of parallel synthesis to generate combinatorial libraries as an efficient means of creating pharmaceutical “drug-like leads” has gained considerable interest.1,2 By accelerating the synthesis and screening of an ever larger number of synthetic analogues, combinatorial chemistry has greatly impacted the drug discovery process.3 Despite this success, compounds originating from nat...

The high yield electrophilic substitution procedure for the synthesis of bis indolyl methanes at room temperature has been carried out effectively by using a novel metal supported organo catalyst. advantages this method include simple conditions, great yields, less work-up, an environmentally friendly process and reusable solid Several were synthesised confirmed IR, H1 13C NMR techniques. Catal...