Rhizome of Costus speciosus has been traditionally used for treating inflammatory and painful conditions. The objective of the present study was to provide a scientific basis for the traditional use. The ethanolic extract of the rhizome of Costus speciosus possesses anti-inflammatory and antipyretic properties. Antiinflammatory property was studied in carrageenan induced paw edema and cotton pe...

The papular variant of elastolytic giant cell granuloma (EGCG) is a rare EGCG, and it occasionally associated with metabolic comorbidities, including diabetes mellitus (DM). Although the mechanisms developing EGCG are still unknown, one possible for ECGC in DM patient might be explained by hyperglycaemia-induced inflammation. In this report, we described case interstitial mainly composed matrix...

The immunological manifestation of granuloma formations in humans largely depends on the delayed-type hypersensitivity response. We investigated the involvement of monocyte chemoattractant protein-1 (MCP-1) in a rabbit model of T cell-mediated pulmonary granulomatosis. Intravenous injection of Propionibacterium acnes (P. acnes) into sensitized rabbits induced massive and diffuse pulmonary granu...

The anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herb Cancrinia discoidea (Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet-induced granuloma rat model of chronic inflammation. Flavone glycoside at doses of 5, 10, or 20 ...

These investigations delineate the recently described suppression of a form of cellular hypersensitivity in mice with streptozotocin-induced diabetes mellitus using a variety of cell-mediated immunologic responses in animals with several different forms of diabetes. Streptozotocin- and alloxan-induced diabetic mice and db/db genetically determined diabetic mice showed reductions in the areas of...

Objective: The objective of the present study was to evaluate the possible analgesic and anti-inflammatory activity of the root of Cucumis callosus (Rottl.) Cogn. (Cucurbitaceae) using different animal models. Materials and Methods: The methanol extract of the identified root part of plant Cucumis callosus was used for the evaluation of antinociceptve effect using three animal models namely; ac...

Accumulating evidence implicates tumor necrosis factor (TNF) and Fas systems in liver injury, although the interaction between these two systems remains to be investigated. In this study, we examined Propionibacterium acnes-primed TNF receptor p55-deficient (TNFRp55-/-) or Fas-deficient MRL/MpJ Lpr/Lpr mice challenged with lipopolysaccharide (LPS). Priming with P. acnes caused mononuclear cell ...

The extract of Chloroxylon sweitenia (Family: Rutaceae) leaves were investigated for its anti-inflammatory activity at the different doses in the standard animal models. The experimental paradigms used were carrageenan induced rat paw oedema (acute), and cotton pellet induced granuloma (chronic) models in rats for anti-inflammatory activity. In rats the toxicity was also performed for the extra...

To investigate the antinociceptive and anti-inflammatory activities of the denatured Naja Naja atra venom (NNAV) in rheumatoid arthritis-associated models, the denatured NNAV (heat treated; 30, 90, 270  μ g/kg), the native NNAV (untreated with heat; 90  μ g/kg), and Tripterygium wilfordii polyglycoside (TWP, 15 mg/kg) were administrated orally either prophylactically or therapeutically. We meas...

Extract of Harpagophytum procumbens (devil's claw) has become the focus of research as a potential therapeutic agent in the treatment of rheumatic arthritis and pain due to its favorable side effects profile compared to synthetic alternatives. This superior safety of treatment is very valuable, especially in view of that in mandatory long duration of therapy in chronic diseases. None of NS...