INTRODUCTION Long-term glucocorticoid therapy, a major risk factor for the development of osteoporosis, is often necessary in chronically ill patients. At present there are no generally accepted guidelines for the prevention or treatment of steroid-induced osteoporosis. METHODS In an open prospective study we investigated 99 patients with chronic rheumatic diseases receiving > or = 5 mg/day o...

Osteoporosis is one of the common degenerative skeletal diseases whose essential mechanism imbalance between bone resorption and formation. Currently, close coordination signaling pathways at genetic level during development a hot topic osteoporosis research. The present study focused on whether pterostilbene protects against hydrogen peroxide (H2O2)-induced osteoblastic cell apoptosis, oxidati...

background: β-thalassemia major is a hereditary life threatening anemia which requires regular blood transfusion. clinical symptoms of the disease are growth retardation, pallor, jaundice and skeletal alternations. the variety of bone disease in thalassemia major is manifested by diffuse bone pain or deformity, spontaneous and pathologic fractures and osteopenia or osteoporosis. this study aime...

Glucocorticoids modify osteoblastic cell differentiation, number, and function. Glucocorticoids stimulate osteoclastogenesis and increase the expression of receptor activator of Nuclear factor-kappaB ligand and colony-stimulating factor-1, and decrease the expression of osteoprotegerin. However, the most significant effect of glucocorticoids in bone is an inhibition of bone formation. This inhi...

Chronic use of corticosteroid is the most common secondary cause of osteoporosis. Contrary to previous belief apart from the primary or the idiopathic type, it occurs in all racial groups, both genders, and at any age. In a large cross sectional study in which 229 corticosteroid users (mean age 61 years, ≥6 months of prednisone, ≥5 mg/day) were compared with 286 controls not taking corticostero...

the effect of tamoxifen citrate on bone mass in immobilization osteoporosis was studied in 10 dogs.osteoporosis was induced by fiberglass cast immobilization of the right hind-limb for 28 days, while the lefthind-limb served as a non-immobilized control. five dogs received tamoxifen citrate (1.5 mg/kg per os) once daily for 28 days; five dogs received no treatment. all dogs were euthanized on d...

Glucocorticoid-induced osteoporosis (GIOP) is one of the most serious adverse effects of glucocorticoids. Despite guidelines on the management of GIOP, effective medications and fracture outpatient clinics, this condition remains under-recognized and under-treated. This review covers recent insights into mechanisms involved in GIOP, monitoring for adverse effects of glucocorticoids on bone and ...

Tenghuang Jiangu Capsule (THJGC) is a Chinese herbal formula used for the treatment of osteoporosis and osteoarthritis in China, but its mechanism treating not clear. The aim this study was to investigate therapeutic effect THJGC on intrinsic through network pharmacology experimental validation. Drugs potential targets were obtained from several reliable databases pharmacology, these integrated...

Glucocorticoid-induced osteoporosis (GIOP) is one of the most important side effects of glucocorticoid use, as it leads to an increased risk of fractures. Recently, many published studies have focused on the cellular and molecular mechanisms of bone metabolism, the pathophysiology of GIOP, and the intervention options to prevent GIOP. In this review, recent advances in GIOP are summarized, part...