Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function. However, it has been difficult to discern its role in the adult brain in influencing complex behavior. Here, we use a recently developed inducible knockout system to show that deleting BDNF in broad forebrain regions of adult mice impairs hippocampal-dependent learning and long-term potentiation. We use the in...

The emergence of resistance to most antimicrobial agents in staphylococci indicates the need for new effective agents in the treatment of staphylococcal infections. Clindamycin is considered to be one safe, effective and less costly agent. We analysed 482 staphylococcal isolates. Detection of inducible clindamycin resistance was performed by the D-test, while the presence of methylases genes: e...

Background Risk stratification in anomalous aortic origin of a coronary artery (AAOCA) is challenged by the lack reliable method to detect myocardial ischemia. We prospectively studied safety and feasibility Dobutamine stress-cardiac magnetic resonance (DSCMR), test with excellent performance adults, pediatric patients AAOCA. Methods Consecutive DSCMR from 06/2014–12/2019 patients≤20 years old ...

Abstract Background Assessment of inducible ischemia with stress cardiovascular magnetic resonance (CMR) is recommended in patients chest pain and intermediate or high pre-test probability coronary artery disease (CAD). We aimed to provide a contemporary quantitative data synthesis on diagnostic accuracy prognostic value CMR stable syndromes. Methods performed systematic review meta-analysis st...

For quite a long time, mainly due to fewer treatment options, Clindamycin have been regarded as an alternative drug effectively manage all Staphylococcus aureus infections. Strains with inducible clindamycin resistance (iMLSB phenotype) raise concerns because therapeutic failure may occur during treatment. is mostly in treating serious infections that cannot be treated by other antibiotics, it ...

Sclerotinia sclerotiorum is a phytopathogenic fungus which causes serious yield losses in canola. A pathogen inducible-promoter can facilitate the production of Sclerotinia-resistant transgenic canola plants. Inthis study, the “gain of function approach” was adopted for the construction of a pathogen-inducible promoter.The synthetic promoter technique was used, which involved the in...

This study aimed to determine the levels of the macrolides-lincosamides-streptogramins B (MLS(B)) resistance phenotype of Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolates from clinical samples. A total of 521 strains of staphylococci, comprising 230 S. aureus and 291 CNS isolates from various clinical samples, were identified by conventional methods. The double-disc tes...

The promyelocytic leukemia line HL-60 can be terminally differentiated in vitro to either monocyte/macrophages or granulocytes. We used this cell line to test whether the state of differentiation of a cell changes its response to interferon (IFN). The characteristics of expression of several IFN-alpha- and IFN-gamma-inducible genes in undifferentiated and differentiated HL-60 cells were examine...