background: erythropoietin (epo) is a glycoprotein hormone function to regulate the production of red blood cells. deficiency of epo is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. availability of recombinant epo has eliminated the need for blood transfusion and now it is extensively used for the treatment of anemia. glycosylation of e...

background: the ability of tumour suppressor protein p53 (p53) to regulate cell cycle processes can be modulated by hepatitis b virus (hbv). while preliminary evidences indicates the involvement of protein-x of hbv (hbx) in altering p53 dna binding, no further data have been accumulated for the significance of serum p53 in chronic hepatitis b virus infected patients. methods: 72 non-cirrhotic a...

in this study fungi isolated from the effluent of ethanol factories were identified. optimal conditions for single cell protein (scp) production and cod reduction of sugar beet stillage are specified for a species of hansenula in a continuous culture. under these conditions 5.7 g dm-3 biomass was produced and 31% of cod was reduced without addition of further nutrients to the beet molasses stil...

BACKGROUND Cryptococcal meningitis is associated with increased intracranial pressure (ICP). Therapeutic lumbar puncture (LP) is recommended when the initial ICP is >250 mm H2O, yet the availability of manometers in Africa is limited and not always used where available. We assessed whether intraocular pressure could be a noninvasive surrogate predictor to determine when additional therapeutic L...

The H3K27 histone methyltransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group protein that plays important roles in many biological processes including cellular differentiation, stem cell biology, and cancer development. Up-regulation of Ezh2 is observed in various human cancers consistent with its role in cell proliferation. Thus, understanding the regulation of Ezh2 may reveal how it c...

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disorder characterised by raised bile acids in foetal-maternal circulation, which threatens perinatal health. During the progression of ICP, the effect of oxidative stress is underscored. Peroxiredoxin-3 (PRDX3) is a mitochondrial antioxidant enzyme that is crucial to balance intracellular oxidative stress. However, the role of...

The Agilent 8800 Triple Quadrupole ICP-MS, also referred to as ICP-QQQ, delivers excellent reaction cell performance due to its MS/MS reaction mode, which is unique to ICP-QQQ. The fi rst quadrupole (Q1), before the Octopole Reaction System (ORS3) cell, operates as a 1 amu mass fi lter, strictly controlling the ions that enter the reaction cell. Only ions with the target analyte mass enter the ...

ICP is a chagasin-family natural tight binding inhibitor of Clan CA, family C1 cysteine peptidases (CPs). We investigated the role of ICP in Trypanosoma brucei by generating bloodstream form ICP-deficient mutants (Deltaicp). A threefold increase in CP activity was detected in lysates of Deltaicp, which was restored to the levels in wild type parasites by re-expression of the gene in the null mu...

programmed cell death-1 (pd-1) and its ligands, pd-l1 and pd-l2, have been regarded as important immune system regulatory molecules. the aberrant expression of the molecules has been related to several autoimmune disorders. this study is aimed to assess the mrna expression level of pd-1, pd-l1, and pd-l2 molecules in the peripheral blood mononuclear mells (pbmcs) from multiple sclerosis (ms) pa...