ulcerative colitis (uc) and crohn's disease (cd) are chronic inflammatory bowel diseases with uncertain etiology thought to be triggered by interactions between various environmental, genetic and immunologic factors. incidence rate of cd and uc is different in various geographic areas around the world, between 0.1-11 and 0.5-24.5 per 100,000 people for cd and uc, respectively. recent studies in...

crohn's disease is a type of chronic inflammatory bowel disease (ibd) of unknown etiology that may affect any part of the gastrointestinal tract from mouth to anus and shows extra-intestinal involvement. it characteristically shows skip lesions. this case report reported in 2014 describes a middle age pakistani male known to have documented evidence of significant crohn's disease since past 18 ...

objective: to compare the efficacy of ceftriaxone plus ofloxacin or azithromycin for cases of pelvic inflammatory disease (pid). materials and methods:   this clinical terial was performed on 180 women with pid from march 2005 to march 2007 in parastarane-shahed hospital. patients with pid were randomly divided to receive injection of ceftriaxone 250 mg plus ofloxacin 200 mg per day or azithrom...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. MS three times more common in women, yet severe men. The mechanisms underlying these sex differences remain largely unknown. initiated by autoreactive T cells, but CNS-infiltrating myeloid cells are key effector driving pathology. role CNS-resident microglial less clear. We have previously sho...

The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines. Segregated into at least two distinct branches, often termed the "neurotoxic" and "neuroprotective" arms of the KP, they are regulated by the two enzymes kynurenine 3-monooxygenase and kynurenine aminotransferase, respectively. Intere...

We describe a 3.5-year-old female with Alpers disease with a POLG genotype of p.A467T/p.G848S and with a lethal outcome. Laboratory investigation revealed elevated CSF neopterin, IL-6, IL-8, IFN-gamma, reduced CSF 5-methyltetrahydrofolate (5MTHF), and increased serum as well as CSF folate receptor blocking autoantibodies. Treatment with oral Leucovorine (5-formyl-tetrahydrofolate) was initiated...

Cerebrospinal fluid (CSF) analysis is one of the most important tests in diagnosis central nervous system (CNS) diseases. Although CSF commonly used neurological pathological conditions, it also has its place psychiatry. Studies to date have described several valuable specific cytomorphological phenomena cerebrospinal patients with acute schizophrenia, which indicate inflammatory or immune-medi...

Fibronectin (FN), a large family of plasma and extracellular matrix (ECM) glycoproteins, plays an important role in leukocyte migration. In normal central nervous system (CNS), a fine and delicate mesh of FN is virtually restricted to the basal membrane of cerebral blood vessels and to the glial limitans externa. Experimental autoimmune encephalomyelitis (EAE), an inflammatory CNS demyelinating...

Neuroinflammation during multiple sclerosis involves immune cell infiltration and disruption of the BBB (blood-brain barrier). Both processes can be visualized by MRI (magnetic resonance imaging), in multiple sclerosis patients and in the animal model EAE (experimental autoimmune encephalomyelitis). We previously showed that VSOPs (very small superparamagnetic iron oxide particles) reveal CNS (...

Multiple sclerosis involves inflammatory immune responses in the central nervous system (CNS) and is considered as an autoimmune disease potentially associated with viral infection. The majority of experimental models rely heavily on the autoimmune components since similar diseases can be induced following immunization with various myelin antigens. A very attractive alternative model is the The...