1. Burn injury stimulates ubiquitin-dependent protein breakdown in skeletal muscle. The 20S proteasome is the proteolytic core of the 26S proteasome that degrades ubiquitin conjugates. We examined the effects of the proteasome inhibitors N-acetyl-L-leucinyl-L-leucinal-L-norleucinal (LLnL), lactacystin and beta-lactone on protein breakdown in muscles from burned rats. 2. A full-thickness burn of...

The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistant Staphylococcus aureus (MRSA). Hexane (ASHE) and dichloromethane (ASDE) extracts were tested. Female BALB/c mice were inflicted with third-degree thermal injury followed by infection with MRSA. ASHE and ASDE formulated with s...

Intentional burns represent a serious form of physical abuse that must be identified to protect children from further harm. This study is a retrospectively planned secondary analysis of the Examining Siblings To Recognize Abuse (ExSTRA) network data. Our objective was to describe the characteristics of burns injuries in children referred to Child Abuse Pediatricians (CAPs) in relation to the pe...

OBJECTIVES The designer antibacterial peptide A3-APO is efficacious in mouse models of Escherichia coli and Acinetobacter baumannii systemic infections. Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. METHODS CD-1 mice were inflicted with burn wounds and different inocula of A. baumannii, isolated from an injur...

BACKGROUND The alarming incidence of self- burning provoked to set up a multidisciplinary preventive program to decrease the incidence and complications of this harmful issue. This study investigated the incidence and the preventive measures in self-burn in Fars Province, southern Iran. METHODS This study was a longitudinal prospective design on trend of self-inflicted burn injuries in Fars p...

background metallo-beta-lactamase (mbl) producing pseudomonas aeruginosa in the burn patients is a leading cause of morbidity and mortality and remains a serious health concern among the clinicians. objectives the aim of this study was to detect mbl-producing p. aeruginosa in burn patients and determine multidrug-resistant (mdr) strains, and respective resistance patterns. patients and methods ...

BACKGROUND Burn injuries are a huge public health issue for children. The aim of this study was to determine the demographic and etiological features, burn wound infections, and clinical trends of 2346 pediatric burns patients over 15 years in the southeast provinces of Turkey and to establish criteria for a pediatric burn prevention program. METHODS Age, gender, degree of burn, demographics,...

conclusions invasive interventions increased bacteremia susceptibility in burn wards. mortality rate had a direct association with bacteremia prevalence and increased by larger burn area. results thirty-nine males (48.1%) and 42 females (51.9%) included with a mean age of 32.06 ± 17.46 years. in patients without bacteremia, 57 patients did not need catheterization (89.1%), however in patients w...

introduction: this paper presents the results of a study on the effects of two differentdoses of low-power laser irradiation on healing of deep second degree burns. material and methods: 60 rats were randomly allocated to one of four groups. adeep second-degree burn was inflicted in each rat. in the control group (cg) burns remained untreated; in groups lg1 and lg2 the burns were irradiated wit...

OBJECTIVE This article describes the characteristics of violence-related injury (VRI) cases presenting at emergency departments (EDs) in Brazil and compares circumstances for assault-related and self-inflicted cases. METHODS The study is cross-sectional. The data describe cases seen in September 2006 in 62 EDs, representing all 26 states and the Federal District. A total of 4 835 case records...