BACKGROUND Smoke inhalation injury refers to airway and lung parenchyma injury and general chemical damage caused by inhaling toxic gases and substances. The aim of this study was to explore the oxidative stress mechanism of cotton smoke inhalation-induced pulmonary injury in a rat model. MATERIALS AND METHODS Eighteen male Sprague-Dawley rats were randomly divided into control group, 6 h gro...

Backgroud: This study was undertaken to identify the role of heparin and Nacetylcystein in prevention of acute respiratory distress syndrome in suspected inhaltion injury in burn Material and Method: One hundred patients were registered with inhalation lung injury in burn unit. Out of these hundred, fifty patients of inhalation injuries have been nebulised with heparin and n-acetylene cysteine ...

The primary cause of death in most smoke inhalation toxicoses in small animals is believed to be carbon monoxide (CO) toxicosis. Thermal injury to the respiratory tract is another part of the syndrome in many cases. Toxic injury to the respiratory tract from noxious gases and particulates is often a third significant component of the process. Chapter Sections Smoke Inhalation Methylene Chloride...

The emergency clinician is frequently called upon to treat burn wounds secondary to thermal, chemical, electrical, or radiation injury. Most burn wounds seen in veterinary medicine are relatively minor, possibly because animals with severe burns and smoke inhalation are less likely to be rescued from the scene of a house fire. However, life threatening burns and inhalation injury are being seen...

Smoke inhalation injury is the leading cause of mortality from structural fires, as a result of complications such as systemic inflammatory response syndrome and chronic obstructive pulmonary disease, which can be caused by a localized or systemic response. In this review, the pathophysiology of smoke inhalation injury, along with the characteristics found in clinical settings, common animal mo...

The present study investigated the effects of diesel exhaust (DE) on an experimental model of bleomycin (BLM)-induced lung injury and fibrosis in mice. BLM was intravenously administered to both Nrf2+/+ and Nrf2-/- C57BL/6J mice on day 0. The mice were exposed to DE for 56 days from 28 days before the BLM injection to 28 days after the BLM injection. Inhalation of DE induced significant inhibit...

Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are hi...

To study the pathophysiological mechanism of progressive hypoxemia after smoke inhalation injury, alterations in ventilation-perfusion ratio (VA/Q) were studied in an ovine model by using the multiple inert gas elimination technique. Because ethane was detected in expired gas of some sheep, we replaced ethane with krypton, which was a unique application of the multiple inert gas elimination tec...

Warm ischemia-reperfusion injury remains a crucial issue in transplantation following the cardiac death of donors. Previously, we showed that surfactant inhalation during warm ischemia mitigated ischemia-reperfusion injury. This study investigated the mechanisms of surfactant inhalation protection of the warm ischemic lung after reoxygenation with ventilation alone. In an isolated rat lung vent...

STUDY OBJECTIVES Inhalation of nitric oxide (NO) can ameliorate pulmonary ischemia/reperfusion (I/R) injury of the lung in several experimental models, but toxic effects of NO were also reported. Here we investigate whether NO inhalation for a short period prior to surgery is sufficient to prevent symptoms of lung I/R injury, especially the inflammatory response. DESIGN Using an in situ porci...