نتایج جستجو برای: intermediate radical

تعداد نتایج: 219788  

Journal: :Chemical communications 2010
Snigdha Roy Amit Basak

A hybrid peptide-enediyne molecule was synthesised and shown to undergo selective intramolecular peptide chain cleavage by the 1,4-diyl radical, the potential intermediate of the enediyne system.

Journal: :Bioscience, biotechnology, and biochemistry 2004
Shizuka Saito Yasuko Okamoto Jun Kawabata

DPPH radical scavenging reactions of protocatechuic acid and its methyl ester were investigated in various solvents. In alcoholic solvents, methyl protocatechuate rapidly scavenged more than four equivalents of the radical, whereas approximately two equivalents were consumed in aprotic solvents. Methyl, ethyl, butyl, isopropyl, and tert-butyl protocatechuates were examined for their DPPH radica...

Journal: :The Biochemical journal 1996
M Minetti D Pietraforte A M Di Stasi C Mallozzi

Previous studies have demonstrated that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes NAD(H) linkage to an active site thiol when it comes into contact with .NO-related oxidants. We found that a free-radical generator 2,2'-azobis-(2-amidinopropane) hydrochloride (AAPH), which does not release either .NO or .NO-related species, was indeed able to induce the NAD(H) linkage to GAPDH. ...

Journal: :Chemistry 2005
Devesh Kumar Sam P de Visser Sason Shaik

Density functional theoretical calculations are used to elucidate the epoxidation mechanism of styrene with a cytochrome P450 model Compound I, and the formation of side products. The reaction features multistate reactivity (MSR) with different spin states (doublet and quartet) and different electromeric situations having carbon radicals and cations, as well as iron(III) and iron(IV) oxidation ...

2016
Kazuto Nakamura Yoshikazu Kitahara Toyomi Satoh Yuji Takei Masashi Takano Shoji Nagao Isao Sekiguchi Mitsuaki Suzuki

BACKGROUND There are no definitive criteria for identifying which patients with The International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical cancer will benefit from adjuvant therapy after radical hysterectomy. The aims of this study were to clarify the efficacy of adjuvant therapy and assess complications after radical hysterectomy in patients with FIGO stage IB1 cervical...

Journal: :Chemical research in toxicology 2012
Goutam Chowdhury Ujjal Sarkar Susan Pullen William R Wilson Anuruddha Rajapakse Tarra Fuchs-Knotts Kent S Gates

Heterocyclic N-oxides are an interesting class of antitumor agents that selectively kill the hypoxic cells found in solid tumors. The hypoxia-selective activity of the lead compound in this class, tirapazamine, stems from its ability to undergo intracellular one-electron reduction to an oxygen-sensitive drug radical intermediate. In the presence of molecular oxygen, the radical intermediate is ...

2017
Elizabeth Pierce Steven O Mansoorabadi Mehmet Can George H Reed Stephen W Ragsdale

Oxalate:ferredoxin oxidoreductase (OOR) is an unusual member of the thiamine pyrophosphate (TPP)-dependent 2-oxoacid:ferredoxin oxidoreductase (OFOR) family in that it catalyzes the coenzyme A (CoA)-independent conversion of oxalate into 2 equivalents of carbon dioxide. This reaction is surprising because binding of CoA to the acyl-TPP intermediate of other OFORs results in formation of a CoA e...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Megan L Matthews Christopher S Neumann Linde A Miles Tyler L Grove Squire J Booker Carsten Krebs Christopher T Walsh J Martin Bollinger

The alpha-ketoglutarate-dependent hydroxylases and halogenases employ similar reaction mechanisms involving hydrogen-abstracting Fe(IV)-oxo (ferryl) intermediates. In the halogenases, the carboxylate residue from the His(2)(Asp/Glu)(1) "facial triad" of iron ligands found in the hydroxylases is replaced by alanine, and a halide ion (X(-)) coordinates at the vacated site. Halogenation is thought...

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