Address for correspondence Mr. Arshad Bashir Khan, Associate Professor, Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur Village, Carmelaram Post Varthur Hobli, Bangalore-560035, India. Phone No: 9740379897 E-mail: [email protected] ABSTRACT Purpose: This review article focuses on providing updated information about targeting the nasal mucosa for drug delivery....

the objective of the present work was to formulate and evaluate mucoadhesive in situ nasal gels of loratadine. this drug delivery system may overcome the first-pass metabolism and subsequently improve the bioavailability of the drug. a total of 16 formulations of in situ nasal gels were prepared using different polymeric ratios of hydroxypropyl methylcellulose (hpmc k-100) and xanthan gum. all ...

OBJECTIVES To identify measurements that may help intra-operative localisation of the sphenopalatine foramen. DESIGN The study used three-dimensional surgical navigation software to study radiological anatomy, in order to define the distances and angulations between identifiable bony landmarks and the sphenopalatine foramen. RESULTS The distance from the anterior nasal spine to the sphenopa...

In the field of nasal delivery, one of the most fascinating applications is the delivery of 20 drugs directly to the central nervous system bypassing the blood brain barrier. This approach would 21 provide a series of benefits, such as dose lowering and direct targeting of potent drugs, ultimately 22 reducing their systemic side effects. Recently, clinical trials have explored the nasal adminis...

In both fasting normal and diabetic subjects, nasally administered insulin achieves significant falls in plasma glucose concentrations. Repeated administration before and during a meal has been necessary to lower postprandial glycaemic excursion in subjects with NIDDM. We have studied the use of Novolin Nasal which employs a non-irritant, lecithin-based enhancer as a vehicle for human insulin, ...

INTRODUCTION The presence of a foreign body in the nose is a relatively uncommon occurrence. Many unusual foreign bodies in the nose have been reported in the literature, but no case of a nasal packing occurring as a foreign body in the nasal cavity for a prolonged time has been found. CASE PRESENTATION We describe a unique case of the largest foreign body left in situ in the nasal cavity for...

is perhaps the most preferred by patients and clinicians alike. However, peroral administration of drugs has disadvantages, such as hepatic first-pass metabolism and enzymatic degradation within the gastrointestinal (GI) tract, that prohibit oral administration of certain classes of drugs, especially peptides and proteins. Consequently, other absorptive mucosa are considered as potential sites ...

Intra-nasal oxygen was introduced by Arbuthnot Lane in 1907, using rubber nasal catheters. This approach was advocated by Adrian Stokes for use in critically ill victims of phosgene gas warfare during World War I.1 However, placement of rubber catheters into the nasal cavity (and often removal) was quite uncomfortable and required some skill (it makes our eyes water just thinking about the proc...

of new drug approval applications submitted to regulatory authorities, pharmaceutical companies are continuing to pursue new delivery methods for their drug products. The inhalation and nasal products had combined sales exceeding US$22 billion in 2007 for treatment of asthma, COPD, allergic rhinitis, influenza, migraine and osteoporosis, and for use in general anaesthesia. 1 One common trend is...