PURPOSE To evaluate the in vivo toxicity and efficacy of previously developed poly-(lactide-co-glycolide)-vancomycin-based microparticles (V-MPLs) for eventual use for endophthalmitis prophylaxis during cataract surgery. METHODS The intraocular vancomycin concentration profile was evaluated after V-MPL injection into the anterior chamber of rabbit eyes. The toxicology of V-MPLs versus MPLs al...

Reply: The finding that an antipsychotic medication with strong a-antagonist properties may have caused IFIS is most interesting. Now that this syndrome of IFIS has been defined, it will be interesting to see to what extent a-antagonists besides tamsulosin are associated with this syndrome. The technique of direct intracameral injection of phenylephrine certainly deserves further study.dDavid F...

CASE REPORT Hydrops occurring in the eye secondary to keratoconus, grade 4. It was managed by sulfur hexafluoride (SF6) gas injected into the anterior chamber, with an early resolution of corneal edema obtained. DISCUSSION Intervention with intracameral SF6 injection has proven to be a safe and effective therapy for early reduction of corneal edema in an eye with Descemet's membrane detachmen...

purpose: to describe the prophylactic patterns for endophthalmitis after cataract surgery in iran. methods: in this cross-sectional study, 486 ophthalmologists, members of iranian society of ophthalmology, who participated in the 20th annual meeting of ophthalmology in december 2010, tehran-iran, filled a self-administered questionnaire. a wide range of ophthalmologists, from all around the cou...

AIM To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP). METHODS In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were treated with intracameral moxifloxacin 0.5% ophthalmic solution (0.5 mg/0.1 mL). The main outcome measures were anterior chamber rea...

Background: Recent years have seen a major change in practice of local anaesthesia (LA) for cataract surgery. Aims: (i) To estimate current usage of LA techniques for cataract surgery, (ii) to estimate the incidence of severe adverse events associated with each LA technique, (iii) to compare with our previous 2003 study. Methods: This was a prospective, observational study of routine practice. ...

BACKGROUND Intraocular cytomegalovirus (CMV) infections, including endotheliitis and retinitis, have been reported to threaten the host's vision. These infections have been treated with systemic or intravitreal GCV injection. Intracameral GCV injection can be an effective treatment option that avoids systemic side effects. The cytotoxic effect of ganciclovir (GCV) on cultured human corneal endo...