PURPOSE Intraductal papillary mucinous neoplasms (IPMN) are known to show a transition from adenoma to carcinoma accompanied by several molecular abnormalities. ATM-Chk2-p53 DNA damage checkpoint activation, which is involved in prevention of the progression of several tumors, was analyzed to evaluate the role of the DNA damage checkpoint in the progression of IPMNs. EXPERIMENTAL DESIGN One h...

Obstructive jaundice caused by metastases to the porta hepatis is often observed in patients with various advanced cancers; however, metastasis of lung cancer to the common bile duct with subsequent development of jaundice is rare. A 75-year-old female with lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutation (15-bp in-frame deletion in exon 19 and T790M in exon 20) de...

The purpose of this study is to evaluate the accuracy of mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging for the diagnosis of intraductal spread of breast cancer following preoperative neoadjuvant chemotherapy. We evaluated a total of 168 areas of normal breast tissue outside the mass in 42 consecutive female patients with breast cancer using each imaging modality...

Although some clinical and radiological features may predict malignancy presence in intraductal papillary mucinous pancreas neoplasms, preoperative diagnosis remains difficult. In this study we present 7 patients with Intraductal Papillary Mucinous Neoplasm (IPMN) studied both with 18FDG-PET and magnetic resonance cholangiopancreatography (MRCP). A focal hypermetabolism was documented in 2 pati...

A 79-year-old Indian male was admitted with upper abdominal discomfort of 1-year duration which was associated with loss of weight and appetite. Serum tumor markers, including carcinoembryonic antigen and carbohydrate antigen 19-9, were within normal limits. A computed tomographic scan demonstrated a cystically dilated and tortuous pancreatic duct measuring 1.9 cm, suggestive of an intraductal ...

The paper presents a clinical case of successful staged endoscopic treatment for giant multiple choledocholithiasis . Conventional surgery was contraindicated in the patient due to significant comorbidities and high anaesthetic risk Contact lithotripsy basic minimally invasive method It combined with balloon dilatation papillosphincterotomy area mechanical intraductal oral transpapillary cholan...

OBJECTIVE To determine the occurrence of new disease in the pancreatic remnant after resection for intraductal papillary mucinous neoplasms. DESIGN A longitudinal level II cohort study. SETTING Virginia Mason Medical Center, Seattle, Washington. PATIENTS The primary cohort was a "resection cohort" of 203 patients who underwent partial pancreatic resection for an intraductal papillary muci...

Mucinous cystic neoplasm (MCN) of the liver is a biliary counterpart of pancreatic MCN, usually occurring in the liver, but occasionally extending to the extrahepatic bile duct [1,2]. We present a case of MCN with extrahepatic bile duct extension diagnosed by peroral video cholangioscopy (POVCS). A 49-year-old woman was admitted with a week of vomiting without abdominal pain, and jaundice. Abdo...

El carcinoma intraductal es una neoplasia maligna de glándulas salivales infrecuente, la cual se caracteriza por un crecimiento predominantemente intraductal, cuyas células poseen fenotipo con características ductales. Histológicamente encuentra compuesto múltiples estructuras quísticas, arquitectura cribiforme y proliferación celular fenestraciones flexibles apariencia reticular irregul...