The rsuiical cyclizations of N-aziridinyl imines and alkyl azides provided reliable methods for the formation of fiveand six-membered carbon-centered and nitrogen-centered radicals from acyclic precursors. NAziridinyl imino and azido groups were utilized as radical precursors as well as radical acceptors in radical cyclization. Furthermore, intramolecular addition of aminyl radicals to carbonyl...

Palladium-catalyzed oxidative cyclization of alkenols provides a convenient entry into cyclic ethers but typically proceeds with little or no diastereoselectivity for cyclization of trisubstituted olefins to form tetrahydrofurans due to the similar energies of competing 5-membered transition-state conformations. Herein, a new variant of this reaction has been developed in which a PdCl2/1,4-benz...

Density functional theory is used to study the mechanism of the title reaction, one of the first catalytic asymmetric 6π-electrocyclizations observed experimentally. The benzylideneacetone-derived phenyl hydrazone is chosen as model substrate for the cyclization reaction, both in the protonated (A) and unprotonated (B) form, while the isoelectronic carbon analogue, 1,5-diphenylpentadienyl anion...