The comparative pharmacokinetic profile of cefquinome was studied in sheep and goats following repeated intramuscular (IM) administrations of 2 mg/kg body weight. Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341) as test organism. Following intramuscular injection of cefquinome in sheep and goats, the disposition curves we...

BACKGROUND Previous studies suggest that caudal administration of ketamine cause effective analgesia. The purpose of the current study was to compare the clinical effectiveness and plasma concentrations of S(+)-ketamine after caudal or intramuscular administration in children to distinguish between local and systemic analgesia. METHODS After induction of general anesthesia, 42 patients, aged ...

In sheep the administration of single intramuscular injections of dexamethasone into the fetus was shown to be an effective method of initiating parturition. In a controlled trial in women who had gone beyond the 41st week of pregnancy 20 mg betamethasone in saline (six patients) or saline alone (five patients) was injected into the amniotic fluid. In the betamethasone-treated group delivery oc...

I n the report by Yin et al, 1 the statement that “many clinicians may misinterpret these directions (in paliperidone palmitate product monograph) to mean that these intramuscular sites (deltoid or gluteal) are interchangeable, and thus therapeutically equivalent” is, in our opinion, not correct. We are writing to clarify some statements from the Yin et al article concerning the deltoid versus ...

The pharmacokinetics of ceftriaxone were investigated in six healthy adults. One-gram doses were administered either intramuscularly or intravenously in a crossover design study. Mean peak ceftriaxone concentrations in plasma of 79.2 and 123.2 micrograms/ml were achieved with intramuscular injection and intravenous infusion, respectively, with plasma half-lives of 5.4 and 5.8 h. The urinary rec...

The rapid corticotropin test with synthetic corticotropin ( 1-24 peptide) was studied. A single intravenous injection of the corticotropin was performed in 26 human subjects. The increment of plasma 11-0HCS concentration by the administration was less than that of NH-corticotropin dripping infusion or synthetic corticotropin intramuscular injection. Intramuscular rapid corticotropin test was co...

With an agreed success rate of about 85 per cent. the role of oral oxytetracycline hydrochloride in the treatment of non-specific urethritis was firmly established a decade ago. Other oral tetracyclines have proved of similar value. While the results obtained with intramuscular oxytetracycline and other tetracyclines have been comparable, the incidence of pain at the injection site has been suc...