Over the last decade there has been a paradigm shift from penetrating keratoplasty (PKP) to lamellar keratoplasty for the management of primary as well as acquired corneal ectasia. Several treatment modalities have emerged including collagen cross-linking, intrastromal implants, laser vision correction, and recent techniques in central and peripheral lamellar keratoplasty. This article reviews ...

CASE REPORT A 31-year-old woman who had undergone surgery for a congenital cataract as a newborn developed bilateral malignant glaucoma, which was refractory to medical-surgical treatment. The patient currently has terminal glaucoma and severe band keratopathy. For aesthetic purposes, we performed intrastromal keratopigmentation surgery using ink for skin tattoos supplied in sterile single-dose...

PURPOSE To observe morphologic and histopathologic changes in the midperiphery of the rabbit cornea produced by femtosecond laser-assisted multilayer intrastromal ablation, determine whether this method may be used to correct myopia, and study how the cornea heals when the epithelium is not injured. METHODS The right eyes of 10 New Zealand White rabbits were used for the experiments. A 60-kHz...

The compounds benzyloxycarbonyl-L-leucyl-hydroxamate (Z-Leu-NHOH), phosphoryl-L-leucyl-L-phenylalanine (P-Leu-Phe) and 2-mercaptoacetyl-L-phenylalanyl-L-leucine (HSAc-Phe-Leu) strongly inhibit the activity of Pseudomonas elastase in vitro. The capacity of these inhibitors to prevent corneal melting and perforation due to the elastase was examined in rabbit eyes by intrastromal injections of ela...

Purpose. To compare stromal riboflavin concentration after three corneal cross-linking (CXL) imbibition procedures: standard (EpiOff), transepithelial corneal (EpiOn), and iontophoresis-assisted technique (Ionto) using 0.1% hypotonic riboflavin phosphate. Methods. Randomized open-label pilot clinical study. Twelve corneas/12 patients with advanced keratoconus were randomly divided into 4 groups...

LASIK (laser-assisted in situ keratomileusis) is a common laser refractive procedure for myopia and astigmatism, involving permanent removal of anterior corneal stromal tissue by excimer ablation beneath a hinged flap. Correction of refractive error is achieved by the resulting change in the curvature of the cornea and is limited by central corneal thickness, as a thin residual stromal bed may ...

A 32-year-old female patient with progressive keratoconus in her right eye was treated with simultaneous customized photoreactive keratoctomy (PRK) and corneal cross-linking (CXL) with riboflavin and Ultraviolet A (UVA) irradiation. Ten days after the procedure, the patient was presented with foreign body sensation, mild ring-shaped corneal infiltration with vascularization at the limbus and Tr...