Cellulitis is treated with antibiotics as routine management and based on the literature cellulitis hospitalization can be avoided by 11% if appropriate are used.1 Randomized clinical trials Cochrane reviews have suggested that oral non-inferior to intravenous administration (1). We would like highlight here unrequired use of in cellulitis. Intravenous recommended patients sepsis. This supporte...

Background: The risk of anesthesia increases with age, so it is necessary to choose a safe and effective method. In this study, we compared the effectiveness of intranasal fentanyl with intravenous fentanyl in patients undergoing cataract surgery. Methods: This study was a triple-blind prospective randomized clinical trial (The patient, physician, and data analyzer were unaware of the patient ...

Cefotaxime is a bactericidal "third generation" cephalosporin has a broad-spectrum activity against gram-positive microorganisms and exceptional activity against most gram-negative microorganisms. Cefotaxime is widely considered to be the antibiotic of choice for the management of neonatal meningitis and sepsis caused by gram-negative bacteria. Cefotaxime is active against Neisseria meningitis,...

The pharmacokinetic profile of sodium meclofenamate, a non-steroidal antiinflammatory drug, was determined in six pre-ruminant calves after intravenous and intramuscular administration at a dose of 2.2mg/kg of body weight. Meclofenamate concentrations were measured using a high performance liquid chromatography assay. The pharmacokinetics of sodium meclofenamate after intravenous and intramuscu...

OBJECTIVES To investigate the concentrations of carboplatin and etoposide achieved in the aqueous and vitreous humors after intravenous infusion in nonhuman primates, and to investigate whether local administration of carboplatin might result in higher concentrations in the vitreous humor. METHODS Macaca fascicularis primates were treated with 1 of 3 regimens: (1) intravenous carboplatin (18....

background : in most iranian hospitals, the nurses in the wards prepare intravenous (iv) drugs and unfortunately pharmacists are not involved in this process. the severity of the patients in intensive care unit (icu) heightens the risk of errors. more over the frequency of using iv drugs in this unit is high, so we decided to determine the frequency and types of errors, which occur in the prepa...

several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-fu related toxicity. the aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-fu in rabbits, mice and dogs. it was further aimed to determine its route related toxicity in rabbits.    plasma concentration of both 5-fu and its metabolite 5-f...