In this work we demonstrate a label-free optical imaging technique to assess metabolic status and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes by two-photon fluorescence lifetime imaging of endogenous fluorophores. Our results show the sensitivity of this method to detect shifts in metabolism and oxidative stress in the cardiomyocytes upon pathological stimuli ...

Here we present a clinical case of cardiac sarcoidosis. The article discusses the difficulties differential diagnosis in patients emergently hospitalized cardiology department with recurrent chest pain, no changes electrocardiogram (ECG), and presumptive acute coronary syndrome without ST segment elevation (NSTE-ACS). A careful history taking, invasive angiography, contrast-enhanced (gadolinium...

Patients scheduled for noncardiac vascular surgery are at significant risk of cardiovascular morbidity and mortality due to underlying symptomatic or asymptomatic coronary artery disease. This review will give an overview of current preoperative cardiac risk assessment strategies for patients undergoing noncardiac vascular surgery. Clinical cardiac risk scores are useful tools for the simple id...

Background: Cardiac magnetic resonance (CMR) imaging with gadolinium-based contrast agents offers unique non-invasive insights into cardiac tissue composition. Myocardial extracellular volume (ECV) has evolved as an objective and robust parameter broad diagnostic prognostic implications. For the gadolinium compound gadobutrol, recommended dose for imaging, including ECV measurements, is 0.1 mmo...

Background Cardiac magnetic resonance imaging (CMR) is increasingly proposed for non-invasive detection of relevant coronary artery disease (CAD), currently using an integrated assessment of myocardial perfusion, viability and function. Magnetic resonance coronary artery imaging (MRCA) is still experimental. Currently, it is not proven if sublingual nitroglycerin (slNitro) should be given to en...

Introduction The combined use of cardiac computed tomography coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance imaging (CMR) has several advantages: it can simultaneous assess myocardial perfusion, ventricular and valvular function, cardiomyopathy and aortic disease and does not ...

Minimally invasive cardiac surgery is less traumatic and therefore leads to quicker recovery. With the assistance of engineering technologies on devices, imaging, and robotics, in conjunction with surgical technique, minimally invasive cardiac surgery will improve clinical outcomes and expand the cohort of patients that can be treated. We used transapical aortic valve implantation as an example...

echocardiography is a non-invasive diagnostic technique which provides information regarding cardiac function and hemodynamics. it is the most frequently used cardiovascular diagnostic test after electrocardiography and chest x-ray. however, in a patient with acute chest pain, transthoracic echocardiography is essential both for diagnosing acute coronary syndrome, zeroing on the evaluation of v...

PURPOSE OF REVIEW Cost-effective care pathways are integral to delivering sustainable healthcare programmes. Due to the overestimation of coronary artery disease using traditional risk tables, non-invasive testing has been utilised to improve risk stratification and initiate appropriate management to reduce the dependence on invasive investigations. In line with recent technological improvement...