Single-Gene Disorders Invasive diagnostic prenatal (fetal) testing for molecular analysis for single-gene disorders may be considered medically necessary when a pregnancy has been identified as being at high risk: 1. For autosomal dominant conditions, at least 1 of the parents has a known pathogenic mutation. 2. For autosomal recessive conditions: a. Both parents are suspected to be carriers or...

background: this research was accomplished to evaluate the ihc expression of p16 (ink4a) and ck17 in low grade cervical intraepithelial lesions (lsil), high grade cervical intraepithelial lesions (hsil) and invasive cervical carcinomas and to assess their correlation to hpv (16e6+18e6). methods: the study included (127) formalin-fixed paraffin-embedded cervical biopsies; of which 22 cases were ...

BACKGROUND A diagnosis of H. pylori infection can be made by invasive or non-invasive methods. Several noninvasive diagnostic tests based on the detection of H. pylori stool antigen (HpSA) have been developed. The Genx H. pylori stool antigen card test is a new rapid, non-invasive test that is based on monoclonal immunochromatographic assay. The aim of this study was to determine its sensitivit...

Objective(s): lupus nephritis (LN) is a severe form of systemic lupus erythematosus (SLE) with renal complications. Current diagnosis is based on invasive renal biopsy and serum antibodies and complement levels that are not specific enough. The current study aims to identify new biomarker candidates for non-invasive diagnosis of LN and explore the pathogenic mechanisms...

background:   objective: this study aimed to evaluate the diagnostic and therapeutical efficiency of hysteroscopy in managing the common conditions including abnormal uterine bleeding, abortion and infertility.   materials and methods: this was a descriptive cross-sectional study to compare hysteroscopy as a minimally invasive approach with conventional laparatomy and hysterectomy or repair of ...

Invasive fungal infections (IFIs) remain a major cause of morbidity and mortality in immunocompromised patients, ranging between 60%-90%, especially in those patients with hematological malignancies who receive induction chemotherapy or undergo hematopoietic stem cell transplantation (HSCT) [1,2]. The critical challenge is achieving an accurate and early diagnosis of IFI and selecting the appro...

We investigate machine learning methods for diagnostic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all types of cancers combined. Early diagnosis of heart disease in women is harder than it is in men and typically requires the administration of several clinical tests on the patient. Most risk stratification methods aggrega...

Background: Screening for varices remains as the best strategy to decrease associated mortality that reaches 25%. Diagnostic endoscopy is gold standard but invasive routine screening. Non-invasive stiffness measurements with elastography costly and impractical. Non-elastogarphic tests use available laboratory clinical variables are feasible their performance inferior elastography. Non-invasive,...