A retrospective study of radiolodine therapy for thyrotoxicosis was done in 402 patients over a period of 10 years from 1963 to 1972. The patients were classified as follows: (1) Age (2) Sex (3) Size of the gland estimated by physical exmination (4) Type of goitre (diffuse, nodular) (5) Ocular signs (6) Number of doses and (7) Total dose of 1-13 1 administered. The usual age for the treatment w...

Isotopes of iodine play significant environmental roles, including a limiting micronutrient ((127)I), an acute radiotoxin ((131)I), and a geochemical tracer ((129)I). But the cycling of iodine through terrestrial ecosystems is poorly understood, due to its complex environmental chemistry and low natural abundance. To better understand iodine transport and fate in a terrestrial ecosystem, we tra...

Since lithium has been shown to inhibit release of iodine from the thyroid, we have investigated its therapeutic potential in thyrotoxicosis. Eight detailed (131)I kinetic studies were performed on seven thyrotoxic women and data was analyzed using a computer program. Lithium at serum levels of about 1 mEq liter decreased the loss of (131)I from the thyroid, led to a fall in serum (131)I levels...

OBJECTIVES To evaluate the efficacy of a fixed dose of radioactive iodine (131-I) in the treatment of thyrotoxicosis, and to identify risk factors associated with treatment failure. DESIGN Retrospective study. SETTING Thyroid Clinic of a regional hospital in Hong Kong. PATIENTS Patients receiving their first dose of radioactive iodine for the treatment of thyrotoxicosis during the inclusi...

UNLABELLED The purpose of this study was to determine the orogastric transit time of standard 131I capsules and the incidence of transit delay. METHODS We studied 58 consecutive subjects receiving outpatient diagnostic and therapeutic 131I dosages. A standard ion chamber survey meter, placed over the left upper quadrant of the abdomen, monitored orogastric transit. Each subject had ample wate...

UNLABELLED The effect of radioiodine in the treatment of nontoxic goiter is seldom evaluated quantitatively. The aim of this study was threefold: (a) to assess the effect of 131I on goiter volume, (b) to establish a relationship between CT volume reduction and the amount of radioactivity taken up by the thyroid and (b) to assess the precision of scintigraphic thyroid volume measurements. METH...

OBJECTIVES X-ray fluorescence (XRF) is a non-invasive method for determining the iodine content of the thyroid gland in vivo. In spite of the obvious clinical value of such a method in situations of iodine deficiency or iodine overload, the method has not so far been widely used. The objective was to investigate the applicability of the XRF method in a larger number of subjects. DESIGN AND SU...

Due to the high variance in available protocols on iodide-131 ((131)I) ablation in rodents, we set out to establish an effective method to generate a thyroid-ablated mouse model that allows the application of the sodium iodide symporter (NIS) as a reporter gene without interference with thyroidal NIS. We tested a range of (131)I doses with and without prestimulation of thyroidal radioiodide upt...

1. A group of normal and congenitally goitrous Merino sheep were investigated to identify the metabolic defect present in the abnormal animals. 2. Protein-bound iodine concentrations of serum from goitrous animals (average 5.7mug./100ml.) were higher than normal (average 4.2mug./100ml.; P 0.001), but the hormonal iodine measured as butanol-extractable (131)I was low in the serum of goitrous (av...