An efficient laboratory experiment has been developed for undergraduate students to conduct hydrogen-deuterium (H-D) exchange of resorcinol by electrophilic aromatic substitution using D2O and a catalytic amount of H2SO4. The resulting labeled product is characterized by 1H NMR. Students also visualize a significant kinetic isotope effect (kH/kD ≈ 3 to 4) by adding iodine tincture to solutions ...

IN THE COURSE of assaying the potency of a variety of fibrinolytic enzyme preparations in dogs and monkeys with isotopelabeled fibrin clots, we observed that the fibrinolytie activity disappeared rapidly from the systemic circulation. Dissolution of blood clots was noted to occur long after the disappearance of measurable circulating fibrinolytic activity. These experimental observations were c...

Technetium-99m MAG3, a technetium-labeled analog of hippuran, was compared with [131I] hippuran using a simultaneous dual isotope study in 20 patients. The plasma clearance for MAG3 was lower than that of hippuran, but its plasma concentration was higher, resulting in similar rates of excretion and similar renal time-activity curves. Apart from better statistics with the technetium-labeled agen...

An air- and moisture-stable fluoroiodane in the presence of AgBF4 is suitable for selective geminal difluorination of styrenes under mild reaction conditions. One of the CF bonds is formed by transfer of electrophilic fluorine from the hypervalent iodine reagent, while the other one arises from the tetrafluoroborate counterion of silver. Deuterium-isotope-labelling experiments and rearrangemen...

IN THE COURSE of assaying the potency of a variety of fibrinolytic enzyme preparations in dogs and monkeys with isotopelabeled fibrin clots, we observed that the fibrinolytie activity disappeared rapidly from the systemic circulation. Dissolution of blood clots was noted to occur long after the disappearance of measurable circulating fibrinolytic activity. These experimental observations were c...

background: to assess accessibility of iodinated salt and urinary iodine concentrations (uic) during pregnancy. this cross-sectional study was carried out between october and december, 2009 in urmia county, west azerbaijan (wa), iran. methods: data on demographic characteristics and iodinated salt accessibility were gathered through a questionnaire at 1st trimester. household salt samples and u...