Nitrogen-containing pyridine and quinoline are outstanding platforms on which excellent ionophores and sensors for metal ions can be built. Steric and stereochemical effects can be used to modulate the affinity and selectivity of such ligands toward different metal ions on the coordination chemistry front. On the signal transduction front, such effects can also be used to modulate optical respo...

Ionomycin and A23187 are divalent cation ionophores with a marked preference for calcium. Studies using these ionophores have almost exclusively interpreted their results in the light of calcium elevation. It was the aim of this study to investigate the effects of ionomycin in osteoblatic MC3T3-E1 cells that are not attributable to its ionophoric properties. Thus, we have found that in contrast...

In the mid-1970s, ionophores were approved by the Food and Drug Administration for addition to the rations of ruminants in the United States. Monensin has been used most extensively, but others, including lasalocid, tetronasin, lysocellin, narasin, and laidlomycin, either have been investigated or are used commercially. lonophores generally have improved the efficiency of feed utilization; with...