نتایج جستجو برای: irak4
تعداد نتایج: 227 فیلتر نتایج به سال:
Death domain (DD) superfamily members play a central role in apoptotic and inflammatory signaling through formation of oligomeric molecular scaffolds. These scaffolds promote the activation of proinflammatory and apoptotic initiator caspases, as well as Ser/Thr kinases. Interactions between DDs are facilitated by a conserved set of interaction surfaces, type I, type II, and type III. Recently s...
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key co...
Recently, mounting evidence indicates that N6-methyladenosine (m6A) modification functions as a pivotal posttranscriptional regulates noncoding RNA biogenesis to influence the progression of multiple diseases. However, whether m6A is involved in aortic dissection (AD) development has never been reported. Meanwhile, numerous studies have shown AngII-induced inflammatory damage and excessive apop...
CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but r...
Background: Oncogenic mutations in myeloid differentiation primary response 88 (MYD88) occur about 25% of diffuse large B-cell lymphoma (DLBCL), including approximately one-third activated (ABC) nodal DLBCL and 70-80% ABC-like extranodal lymphomas, are associated with poor survival. MYD88 also up to 90-95% patients Waldenström’s Macroglobulinemia (WM). These result activation the NF-κB pathway ...
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