The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years. The survey included populations living at altitudes between 156 to 3750 m. Body iron stores in the mothers averaged 3.88 +/- 4.31 mg/kg (mean +/- 1 SD) and 1.72 +/- 4.53 mg/kg in chil...

BACKGROUND Epidemiologists have observed that blood donation is associated with decreased risk of type 2 diabetes and cardiovascular disease. METHODS We investigated the relationship between iron stores and insulin sensitivity, after controlling for known confounding factors, and compared insulin sensitivity between blood donors and individuals who had never donated blood (nondonors). In 181 ...

Given its potential toxicity and low bioavailability, iron metabolism in humans is a tightly regulated process. Two main levels of regulation have been described: a cellular regulation that, through the binding of iron-responsive proteins (IRPs) to iron-responsive elements in mRNA from genes encoding proteins of iron metabolism, controls the synthesis of transferrin receptor (necessary for cell...

Although, iron depletion is a common disorder among athletes, little data exist regarding the effect of gymnastic training on iron status. The objective of this study was to evaluate the effect of gymnastic exercise on body iron status and hematologic profile. The present investigation involved 35 male gymnasts aged from 6 to14 yrs. Serum ferritin level, total iron binding capacity (TIBC), iron...

BACKGROUND Despite several, well-documented pro-healthy effects of regular physical training, its influence on body iron stores in elderly people remains unknown. At the same time, body iron accumulation is associated with high risk of different morbidities. PURPOSE We hypothesized that Nordic Walking training would result in pro-healthy changes in an elderly group of subjects by reducing bod...

Chronic kidney disease (CKD) is the gradual, progressive deterioration of kidney function, and a condition that affects an estimated 26 million American adults. A common complication of CKD is anemia, which results from inadequate erythropoietin or from iron deficiency as a result of inadequate absorption or mobilization. The management of anemia in CKD patients must strike an appropriate balan...

Serum ferritin, liver iron stores, and liver histology were studied in 38 children with thalassaemia major who were being treated by regular blood transfusions. There was no correlation between serum ferritin levels and either the number of transfusions or the amount of iron deposited in the liver. However, for a given level of iron stores, ferritin levels were higher in patients with chronic h...

BACKGROUND AND OBJECTIVE Emerging evidence from biological and epidemiological studies has suggested that body iron stores and heme-iron intake may be related to the risk of type 2 diabetes (T2D). We aimed to examine the association of body iron stores and heme-iron intake with T2D risk by conducting a systematic review and meta-analysis of previously published studies. RESEARCH DESIGN AND ME...

Immunoradiometric analysis has made it possible to measure ferritin reliably in serum. The determination is a sensitive means of assessing body iron because concentrations of ferritin closely parallel the body's reticuloendothelial iron stores. The information provided is similar to that obtained from bone-marrow aspirates or biopsies stained for iron with Prussian Blue. Comparative studies ind...

OBJECTIVE By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin lev...