BACKGROUND Considerable variation in the prevalence of childhood asthma and its symptoms (wheezing) has been observed in previous studies and there is evidence that the prevalence has been increasing over time. METHODS We have systematically reviewed the reported prevalence and time trends of wheezing symptoms among children, worldwide and within the same country over time. All studies compri...

SUMMARY An ultrafast DNA sequence aligner (Isaac Genome Alignment Software) that takes advantage of high-memory hardware (>48 GB) and variant caller (Isaac Variant Caller) have been developed. We demonstrate that our combined pipeline (Isaac) is four to five times faster than BWA + GATK on equivalent hardware, with comparable accuracy as measured by trio conflict rates and sensitivity. We furth...

BACKGROUND Most of the studies investigating the prevalence of asthma in various countries have focused on children below the age of 15 years or adults above the age of 18 years. There is limited knowledge concerning the prevalence of asthma in 16- to 18-year-old adolescents. Our objective was to study the prevalence of asthma and associated symptoms in 16- to 18-year-old adolescents in Saudi A...

A asma é uma doença multifatorial, em que a predisposição genética é fortemente influenciada pelas pressões externas. Os achados de Alves et al. 1, em artigo publicado em Cadernos de Saúde Pública, apontam associação entre sintomas de asma e indicadores de exposição à violência comunitária em estudo de base populacional em Salvador, Bahia. Entretanto, outros fatores podem interferir na interpre...

BACKGROUND Multiple population-based and high-risk cohort studies use parental questionnaire responses to define allergic rhinitis (AR) in children. Individual questionnaire items have not been validated by comparison with physician-diagnosed AR (PDAR). OBJECTIVE To identify routine clinical questions that best agree with a physician diagnosis of AR and can be used for early case identificati...

Using the international study of asthma and allergies in childhood (ISAAC) questionnaire, 3000 children aged 6-7 years from various schools in the north east of England were studied. In this population, the lifetime prevalence rates of various symptoms and diagnoses were: wheezing, 29.6%; atopic eczema, 27.8%; rhinitis, 23. 1%; and self reported asthma, 22.7%. Rhinitis was reported by 44% and 4...

Diet and asthma, allergic rhinoconjunctivitis and atopic eczema symptom prevalence: an ecological analysis of the International Study of Asthma and Allergies in Childhood (ISAAC) data. P. Ellwood, M.I. Asher, B. Björkstén, M. Burr, N. Pearce, C.F Robertson and the ISAAC Phase One Study Group. #ERS Journals Ltd 2001. ABSTRACT: Several studies have suggested that the increasing prevalence of symp...

Methods Cross-sectional study using the adapted and validated ISAAC Written Questionnaire for Asthma for telephone interview. The sample was the systematic random type without replacement for school classes and students. Data were collected by a polling company from May/ July 2010. Bivariate analyses between asthma ("wheezing in the last 12 months”) and the study factors were performed using od...