OBJECTIVE To examine the impact of heart failure (HF) aetiology on long-term outcome after cardiac resynchronisation therapy (CRT). DESIGN Prospective cohort study. SETTING University hospital. PATIENTS 119 patients (44% with ischaemic and 56% non-ischaemic aetiology) who underwent CRT. INTERVENTIONS Clinical follow-up for 39 (24) months. MAIN OUTCOME MEASURES Cardiovascular mortality...

BACKGROUND In Zambia, 14.2% of adults have HIV/AIDS. There has been a substantial and significant increase in patients hospitalized for ischaemic stroke with co-existing HIV infection. However, little is known about the mechanism of stroke in these HIV + ve patients let alone studied in our region. The aim of this pilot study was to explore the association of hypercoagulability state in HIV + v...

OBJECTIVE To identify any underinvestigation of older patients with transient ischaemic attack (TIA) and stroke. DESIGN Comparative population based studies. SETTING Routine clinical practice in all secondary care services in Oxfordshire and a nested population based study of incidence of transient ischaemic attack and stroke (the Oxford vascular study-OXVASC). PARTICIPANTS/POPULATION: All ...

OBJECTIVES A severe donor organ shortage leads to the death of a substantial number of patients who are listed for transplantation. The use of hearts from donors after circulatory death could significantly expand the donor organ pool, but due to concerns about their viability, these are currently not used for transplantation. We propose short-term ex vivo normothermic machine perfusion (MP) to ...

AIMS To determine whether an increase in vascular resistance in the central retinal and ophthalmic arterial circulations contributes to the development of central retinal vein occlusion (CRVO), or haemodynamic alterations in central retinal and ophthalmic arteries occur secondary to the vein occlusion as increased intravascular pressure is transferred through the capillary bed to the arterial s...

Globally, 9 million people die each year from ischaemic heart disease. Despite falling rates of disease, tackling it is still a stubborn challenge.

Aims We examined the efficacy and safety of dapagliflozin, compared with placebo, according to aetiology in patients heart failure (HF) reduced ejection fraction (HFrEF) enrolled Dapagliflozin And Prevention Adverse-outcomes Heart Failure trial (DAPA-HF). Methods results Aetiology was investigator-reported categorized as ischaemic or non-ischaemic. The primary outcome composite an episode worse...

Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 microg.da...

OBJECTIVE To compare pulmonary function and respiratory muscle strength in patients with ischaemic and idiopathic dilated cardiomyopathy, well matched for indices of heart failure. METHODS The study involved 30 patients with ischaemic cardiomyopathy and 30 with idiopathic dilated cardiomyopathy. The groups were well matched for age, weight, and clinical severity of cardiac dysfunction as asse...