The present study investigates the effect of Withania somnifera (WS), a well-known adaptogenic agent in Indian system of Medicine, on acute cerebral reperfusion and long-term cerebral hypoperfusion in rats. Acute ischemiareperfusion (30 min occlusion of bilateral common carotid arteries followed by 45 min. reperfusion) and Long-term cerebral hypoperfusion (for 15 days) in C.F. strain rats were ...

genesis of ischemia and reperfusion injury in the myocardium. Recent studies have suggested that a massive Ca influx may occur as a consequence of Na –Ca exchange via the sodium–calcium exchanger (NCX) during reperfusion which, in turn, may be caused by an accumulation of Na via the sodium–hydrogen exchanger (NHE) during ischemia. This results in an intracellular Ca overload, the detrimental ef...

This study was designed to define the effect of postischemic low Ca perfusion on recovery of high-energy phosphates, intraceUular pH, and contractile function in isolated rat hearts. Phosphorus-31 nuclear magnetic resonance spectroscopy was used to follow creatine phosphate, adenosine triphosphate, intraceUular inorganic phosphate, and intraceUular pH during control perfusion (15 minutes), tota...

Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important role in renal tubular injury and regeneration in acute kidney injury. However, its role in the development of renal fibrosis, often a long-term consequence of acute kidney injury, is unknown. Using amousemodel of renal fibrosis induced by ischemia-reperfusion injury, we demonstrate increased GSK3β e...

In this paper instrumental methods of carbon dioxide (CO₂) detection in biological material were compared. Using cis-[Cr(C₂O₄)(pm)(OH₂)₂]⁺ cation as a specific molecular biosensor and the stopped-flow technique the concentrations of CO₂ released from the cell culture medium as one of final products of pyruvate decomposition caused by hydrogen peroxide were determined. To prove the usefulness of...

Introduction: Postoperative neurological deficit is the most devastating complication after thoracoabdominal aortic aneurysm repair. Despite demonstrated neuroprotective effects of estradiol, its protective efficacy against spinal cord ischemia-reperfusion and underlying mechanisms are not yet elucidated. Methods: Two groups, each of 10 New Zealand white male rabbits, were studied. Control grou...

Lung transplantation is a well-accepted life-saving treatment for end-stage lung diseases. However, the short-term and long-term success of lung transplantation is hindered by multiple factors such as the shortage of organ donors, primary graft dysfunction, life-long immunosuppression and chronic graft dysfunction. Gene transfection presents a potential molecular therapeutic solution to these p...

Purpose: Ischemic preconditioning (IPC) has been used to protect myocardial cells against ischemiareperfusion injury and is recently utilized for improving exercise performance. It is unknown whether remote IPC (RIPC) to tissues not involved in exercise can induce similar exercise improvements and what “dose” of IPC is necessary to induce exercise performance benefits. This study determined if ...

The present 15 days study was undertaken to evaluate the cardioprotective potential of the prenylated isoflavones osajin and pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. The study was performed on isolated, modified Langendorff-perfused rat hearts and the ische...

IL-22 is currently a hot topic, with researchers generating approximately 400–500 related articles per year. However, articles by Xu et al. and Kulkarni et al. in this issue of JASN are the first to describe the involvement of IL-22 in the kidney.1,2 Interest in IL-22 is growing because of its unique range of cellular targets and the power of its effects,3,4 which are generating increasing exci...