BACKGROUND AND PURPOSE The development of stroke has been linked to lowered levels of epoxyeicosatrienoic acids in the cerebral microvasculature. These substances are metabolized by the enzyme-soluble epoxide hydrolase encoded by the EPHX2 gene. We tested whether genetically reduced soluble epoxide hydrolase activity is associated with risk of ischemic stroke, myocardial infarction, and ischemi...

UNTIL THE ADVENT OF GT SCANNING, the diagnosis of cerebral infarction was based mainly on clinical criteria with lumbar puncture, angiography, and Tc scans affording supplementary evidence. Autopsy showed that the diagnosis often was in error. In particular, a clear differentiation between ischemic infarction and a smaller intracerebral hemorrhage was impossible. Today this situation has change...

Seroepidemiology, pathology, and animal studies provide evidence for a possible association between Chlamydia pneumoniae infections and atherosclerosis, coronary heart disease, and myocardial infarction. If this association exists, then exposure to certain antibiotics may positively affect the clinical course after an acute ischemic cardiac event (secondary prevention) and affect the risk of de...

BACKGROUND We analyzed temporal trends in the incidence of myocardial infarction and ischemic stroke in Sweden by socioeconomic position and investigated whether social inequalities in incidence of these diseases changed over time. MATERIALS AND METHODS We studied a cohort of almost three million Swedish residents born between 1932 and 1960 followed from 1987 until 2010. Incident cases of myo...

BACKGROUND Hemorrhagic complications are quite common in the rare cases where thrombolysis is performed. Ischemic stroke in the aftermath of thrombolysis for a ST elevation myocardial infarction is a very rare and paradoxical complication. With these observations in mind we report two interesting cases of ischemic stroke which occurred after fibrinolytic therapy with tenecteplase for a ST eleva...

UNTIL THE ADVENT OF GT SCANNING, the diagnosis of cerebral infarction was based mainly on clinical criteria with lumbar puncture, angiography, and Tc scans affording supplementary evidence. Autopsy showed that the diagnosis often was in error. In particular, a clear differentiation between ischemic infarction and a smaller intracerebral hemorrhage was impossible. Today this situation has change...

OBJECTIVE To investigate whether transient ischemic attack (TIA) had an ischemic preconditioning neuroprotective effect on subsequent cerebral infarction. PATIENTS AND METHODS 232 patients with cerebral infarction were selected and divided into Group A (<55 years old), Group B (55-75 years old) and Group C (>75 years old), according to age. Each group was further divided into sub-groups A1, A...

numerous etiologies are responsible for cases of stroke in young adults. this study reviews the causes of two types of stroke (ischemic and intracerebral hemorrhage) in young adults aged 15 to 40years, admitted to our center (a tertiary care center) from 1997 to 2002. the purpose of this study is to determine the relative frequency of causes of stroke in young adults and compare this with publi...

Background & Aims: Ischemic postconditioning, conducted by a series of brief occlusion and release of the bilateral common carotid arteries, has neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion but its delayed neuroprotective effects in the embolic model of stroke, especially in female rat, have not yet been reported and were investigated ...