Submit Manuscript | http://medcraveonline.com Abbreviations: SPR: Surface plasmon resonance; ISFET: Ion Sensitive Field Effect Transistor; EnFET: Enzyme Field Effect Transistor; μTAS: Micro Total Analysis System; HCMV: Human Cytomegalovirus; ELISA: Enzyme-Linked Immunosorbent Assay; CNC: Computer Numerical Control; CAD: Computer Assisted Design; BSA: Bovine Serum Albumin; HPAb: Human Polyclonal...

A comprehensive study of the drain current drift mechanism and hysteresis phenomena in fabricated p-channel junctionless ion-sensitive field-effect transistor (JL-ISFET) has been investigated for first time. The measurements have performed through transient analysis current, under different pH liquid-gate bias (Vlg). Further, time-dependent gate-capacitance (CG) also analyzed to see effect hydr...

The use of deoxyribonucleic acid (DNA) hybridization to detect disease-related gene expression is a valuable diagnostic tool. An ion-sensitive field-effect transistor (ISFET) with graphene layer has been utilized for detecting DNA hybridization. Silicene two-dimensional silicon allotrope structural properties similar graphene. Thus, it recently experienced intensive scientific research interest...

Responses on a stepwise. increase of the electrolyte concentration of bare ISFETs can interfere with responses of an ISFET with an affinity membrane deposited on the gate. In this paper the responses of bare ISFETs are studied. Results of experiments and simulations are presented and the mechanism is explained.

After having considered the general definition of biosensors, the specifications of one type are discussed here in more detail, namely the pH-sensitive ISFET, which is at present being clinically investigated for intravascular blood pH recording. Results, advantages and possible improvements will be discussed, as well as a prediction with respect to future developments of FET-based biosensors.

The ion-sensitive field-effect transistor (ISFET) that is designed to detect a specific ionic activity is susceptible to interfering ions in mixed-ion environments causing the sensor to produce deceptive signals. The objective of this work is to improve the interpretation of ISFET signals in mixed-ion environments. The focus of the research is relating sensor signal to the targeted ion concentr...

This publication presents a novel ISFET-based measurement concept for the determination of the zeta potential, which is known to be an efficient method for the detection of protein accumulations onto surfaces. The basic set-up consists of two monolithically integrated ISFET sensors arranged in a serial flow configuration together with a precoated fused silica capillary, which provides the react...

The ion-step method was originally designed to measure immunoreactions via the change in charge density which occurs in an antibody loaded membrane, deposited on an ISFET, upon reaction with a charged antigen. In this paper we show the possibility of detecting an immunoreaction involving a non-charged antigen, progesterone, by using competitive binding of progesterone and a charged progesterone...