Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of some ATP suppliers are investigated against mitochondrial toxicity of PG in isolated rat mitochondria. Mitochondrial viability was investigated by MT...

Sarkissian (4) and Sarkissian and Srivastava (6) have pointed out a close correlation between complementation and heterosis effects with intact mitochondria isolated from wheat coleoptiles. In their experiments, mitochondria which were isolated from coleoptiles of heterozygous F1 plants show significantly higher values for 02 uptake, esterification of inorganic phosphate, and especially for res...

A simple and fast method of lipid analysis of isolated intact mitochondria by means of MALDI-TOF mass spectrometry is described. Mitochondria isolated from bovine heart and yeast have been employed to set up and validate the new method of lipid analysis. The mitochondrial suspension is directly applied over the target and, after drying, covered by a thin layer of the 9-aminoacridine matrix solu...